Author

P. Lak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 2 Approach:mechanistic / dynamical model· 2 Organism:mouse· 2 Assay:structural biology· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

B. K. Shoichet· 3 shared A. Basbaum· 2 shared B. L. Roth· 2 shared H. R. O'Donnell· 2 shared I. Singh· 2 shared V. Craik· 2 shared A. Agrawal· 1 shared A. E. Carpenter· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiophysics

B. K. Shoichet

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Author profile →

5 papers

Recent·Most cited

Reference compounds for characterizing cellular injury in high-content cellular morphology assays

J. L. Dahlin, B. K. Hua, B. E. Zucconi, S. D. Nelson, S. Singh, A. E. Carpenter, J. H. Shrimp, E. Lima-Fernandes, M. J. Wawer, L. P. Chung, A. Agrawal, M. O'Reilly, D. Barsyte-Lovejoy, M. Szewczyk, F. Li, , B. K. Wagner

The paper profiles 218 cytotoxic and nuisance compounds in U-2 OS cells to create reference compounds for improving assay optimization and compound prioritization in cellular morphology assays.

bioRxiv · Jul 12, 2022 · PreprintPharmacology & Toxicology

Structure-based Discovery of Conformationally Selective Inhibitors of the Serotonin Transporter

I. Singh, A. Seth, C. B. Billesbolle, J. Braz, R. M. Rodriguiz, K. Roy, B. Bekele, V. Craik, X.-P. Huang, D. Boytsov, P. Lak, H. R. O'Donnell, W. R. Sandtner, B. L. Roth, A. Basbaum, , G. Rudnick

The paper identifies two novel inhibitors of the serotonin transporter that selectively target the inward-open conformation, showing improved potency and reduced off-target effects compared to existing drugs.

bioRxiv · Jun 13, 2022Biochemistry

Structure-based design of a chemical probe set for the 5-HT5A serotonin receptor

A. L. Kaplan, R. T. Strachan, J. M. Braz, V. Craik, S. Slocum, T. Mangano, V. Amabo, H. R. O'Donnell, P. Lak, A. Basbaum, B. L. Roth, B. K. Shoichet

The paper develops a more selective chemical probe set for the 5-HT5A receptor, showing improved selectivity and reduced assay liabilities compared to the existing SB-699551 antagonist.

bioRxiv · Dec 6, 2021 · PreprintBiophysics

Energy Penalties Enhance Flexible Receptor Docking in a Model Cavity

A. S. Kamenik, I. Singh, P. Lak, T. E. Balius, K. R. Liedl, B. K. Shoichet

The paper tests flexible receptor docking with energy penalties using MD simulations on T4 Lysozyme L99A, identifying new ligands and confirming their binding through experimental methods.

bioRxiv · Apr 20, 2021Biophysics

Conserved tau microtubule-binding repeat histidines confer pH-dependent tau-microtubule association

R. A. Charafeddine, W. A. Cortopassi, P. Lak, M. P. Jacobson, D. L. Barber, T. Wittmann

This study identifies conserved histidine residues in tau that act as pH sensors modulating tau-microtubule binding through electrostatic and hydrophobic interactions.

bioRxiv · Dec 4, 2018Cell Biology