Author

A. M. Gorman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Samali· 2 shared A. Carlesso· 1 shared A. Etcheverry· 1 shared A. Pandit· 1 shared C. Chintha· 1 shared e. chevet· 1 shared G. Jegou· 1 shared J. B. Patterson· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

A. Samali

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Author profile →

2 papers

Recent·Most cited

Cancer BiologybioRxivFeb 20, 2020

Local intracerebral Inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo.

P.-J. Le Reste, R. Pineau, K. Voutetakis…·e. chevet

The paper develops a novel immunocompetent GBM model to test the effect of IRE1 inhibition on treatment efficacy in vivo.

DOI 10.1016/j.canlet.2020.08.028

mouseexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivAug 22, 2019

Structural distortions induced by Kinase Inhibiting RNase Attenuator (KIRA) compounds prevent the formation of face-to-face dimers of Inositol Requiring Enzyme 1α

A. Carlesso, C. Chintha, A. M. Gorman…·L. A. Eriksson

This paper investigates how KIRA compounds disrupt IRE1α dimer formation, inhibiting RNase activity and UPR activation through structural and computational analysis.

DOI 10.3390/ijms20225538

humanprotein structure

𝕏 PostBluesky