Author

A. Samali

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. M. Gorman· 2 shared A. Pandit· 2 shared e. chevet· 2 shared J. B. Patterson· 2 shared J. Samal· 2 shared K. Voutetakis· 2 shared P.-J. Le Reste· 2 shared R. Pineau· 2 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

A. M. Gorman

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Downregulation of miR-17-92 cluster by PERK fine-tunes unfolded protein response mediated apoptosis

D. Read, A. Gupta, K. Cawley, L. Fontana, P. Agostinis, A. Samali, S. Gupta

The paper shows that PERK-mediated repression of miR-17-92 cluster promotes ER stress-induced apoptosis through NRF2.

bioRxiv · Oct 26, 2020Cell Biology

Local intracerebral Inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo.

P.-J. Le Reste, R. Pineau, K. Voutetakis, J. Samal, G. Jegou, S. Lhomond, A. M. Gorman, A. Samali, J. B. Patterson, Q. Zeng, A. Pandit, M. AUBRY, N. Soriano, A. Etcheverry, J. Mosser, , e. chevet

The paper develops a novel immunocompetent GBM model to test the effect of IRE1 inhibition on treatment efficacy in vivo.

bioRxiv · Feb 20, 2020Cancer Biology

Constitutive UPRER activation sustains tumor cell differentiation

D. Doultsinos, M. McMahon, K. Voutetakis, J. Obacz, R. Pineau, P.-J. Le Reste, A. Obiedat, J. Samal, J. B. Patterson, Q. Zheng, A. Samali, A. Pandit, B. Tirosh, A. Chatziioannou, E. Chevet, T. Avril

The paper shows that constitutive IRE1 activation maintains differentiation in glioblastoma cells by repressing stemness factors.

bioRxiv · Oct 22, 2019 · PreprintCancer Biology

Structural distortions induced by Kinase Inhibiting RNase Attenuator (KIRA) compounds prevent the formation of face-to-face dimers of Inositol Requiring Enzyme 1α

A. Carlesso, C. Chintha, A. M. Gorman, A. Samali, L. A. Eriksson

This paper investigates how KIRA compounds disrupt IRE1α dimer formation, inhibiting RNase activity and UPR activation through structural and computational analysis.

bioRxiv · Aug 22, 2019Biochemistry