Author

A. Manghrani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell-cell communication· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Assay:long-read sequencing· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. K. Rangadurai· 2 shared B. Liu· 2 shared H. Al-Hashimi· 2 shared H. M. Al-Hashimi· 2 shared O. Szekely· 2 shared S. Guseva· 2 shared A. Geng· 1 shared A. Liu· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

A. K. Rangadurai

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4 papers

Recent·Most cited

Quantitative and systematic NMR measurements of sequence-dependent A-T Hoogsteen dynamics uncovers unique conformational specificity in the DNA double helix

A. Manghrani, A. K. Rangadurai, O. Szekely, B. Liu, S. Guseva, H. Al-Hashimi

This study measures sequence-dependent A-T Hoogsteen dynamics in DNA using NMR, revealing distinct conformational specificity and sequence dependence.

bioRxiv · May 15, 2024 · PreprintBiochemistry

NMR measurements of transient low-populated tautomeric and anionic Watson-Crick-like G·T/U in RNA:DNA hybrids: Implications for the fidelity of transcription and CRISPR/Cas9 gene editing

O. Szekely, A. K. Rangadurai, S. Gu, A. Manghrani, S. Guseva, H. Al-Hashimi

This study uses NMR to show that G*T/U mismatches in RNA:DNA hybrids can form Watson-Crick-like conformations, potentially contributing to transcription errors and CRISPR/Cas9 off-target effects.

bioRxiv · Aug 24, 2023Biophysics

RNA conformational propensities determine cellular activity

M. L. Kelly, R. Roy, A. Geng, L. R. Ganser, A. Manghrani, B. R. Cullen, U. Schulze-Gahmen, D. Herschlag, H. M. Al-Hashimi

The paper alters and measures conformational propensities of HIV-1 TAR RNA to predict binding affinities and cellular activity.

bioRxiv · Dec 5, 2022 · PreprintBiophysics

Hoogsteen base pairs increase the susceptibility of double-stranded DNA to cytotoxic damage

Y. XU, A. Manghrani, B. Liu, H. Shi, U. Pham, A. Liu, H. M. Al-Hashimi

This study shows that Hoogsteen base pairs in dsDNA increase susceptibility to methylation damage, challenging the assumption that Watson-Crick faces are fully protected.

bioRxiv · May 24, 2020Biochemistry