CXCR4 intracellular protein regulates drug resistance and tumorigenic potential via modulating the expression of Death Receptor 5
M. A. Nengroo, S. Maheshwari, A. Singh…·D. Datta
The paper shows that intracellular CXCR4 protein, not its signaling, promotes drug resistance and tumorigenicity by downregulating DR5 through transcription factor modulation.