A. Pepe

Biophysical modeling identifies an optimal hybrid amoeboid-mesenchymal mechanism for maximal T cell migration speeds

This study identifies that T cells achieve maximal migration speeds by combining bleb formation with adhesion-based forces, challenging the feasibility of adhesion-free migration.

Tunneling nanotubes enable intercellular transfer in zebrafish embryos

This study demonstrates the presence of functional tunneling nanotubes (TNTs) in zebrafish embryos, showing their ability to transfer soluble cargoes and organelles.

mRNA challenge predicts brain cancer immunogenicity and response to checkpoint inhibitors

The paper develops an mRNA vaccine to predict brain tumor response to checkpoint inhibitors by analyzing cytokine release patterns in vitro.

Three-Dimensional Bioconjugated Liquid-Like Solid (LLS) Enhance Characterization of Solid Tumor - Chimeric Antigen Receptor T cell Interactions

This study uses 3D bioconjugated liquid-like solids to model tumor-immune interactions, showing CAR T cells can infiltrate and kill cancer cells while revealing immune escape mechanisms.

N-Cadherin and alpha-catenin regulate formation of functional tunneling nanotubes

This study shows N-Cadherin and alpha-catenin regulate TNT formation and material transfer.

Tunneling nanotubes provide a novel route for SARS-CoV-2 spreading between permissive cells and to non-permissive neuronal cells.

This study shows SARS-CoV-2 uses tunneling nanotubes to spread between permissive cells and infect non-permissive neuronal cells.