A. Powers

Disrupted RNA editing in beta cells mimics early stage type 1 diabetes

Disrupted RNA editing in beta cells leads to an interferon response and diabetes, mimicking early-stage type 1 diabetes without viral infection.

Fragment-Based Ligand Generation Guided By Geometric Deep Learning On Protein-Ligand Structure

The paper develops a method to expand small fragment-like molecules bound to protein pockets into larger drug-like molecules using geometric deep learning.

Reprogrammed Schwann cells organize into dynamic tracks that promote pancreatic cancer invasion

This study shows that Schwann cells activated by cancer cells form tracks that promote pancreatic cancer invasion through c-Jun-dependent mechanisms.

Alpha cell dysfunction in early type 1 diabetes

The paper identifies early alpha cell dysfunction in individuals with GADA+ status, preceding beta cell loss in T1D, and links it to metabolic pathway abnormalities.

Coordinated interactions between endothelial cells and macrophages in the islet microenvironment promote beta cell regeneration