Author

A. Saunders

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2 Cancer Biology· 1 Cell Biology· 1 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

H. Linley· 2 shared R. L. Tarleton· 2 shared S. Hamer· 2 shared S. Jaigirdar· 2 shared A. Dayoub· 1 shared A. E. Smith· 1 shared A. Gasco Hernandez· 1 shared A. Ho· 1 shared

Activity by Year

2022-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersImmunology

H. Linley

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Serial "deep-sampling" PCR of fragmented DNA reveals the wide range of Trypanosoma cruzi burden among chronically infected hosts and allows accurate monitoring of parasite load following treatment

B. E. White, C. Hodo, S. Hamer, A. Saunders, S. Laucella, D. Hall, R. L. Tarleton

This study introduces deep-sampling PCR to detect and quantify T. cruzi parasite load in chronically infected hosts, revealing large variations in parasite levels and enabling treatment monitoring.

bioRxiv · Jun 10, 2024 · PreprintMicrobiology

Reevaluating the Concept of Aging: Long-Term Stress Adaptation as a Key Factor in Yeast Aging

Y. Kong, D. Adejoro, C. Winefield, S. On, P. A. Wescombe, A. Subbaraj, A. Saunders, V. Chelikani

This study investigates how short-term and long-term stress affect yeast aging through transcriptomic and metabolomic analyses, finding that long-term stress activates aging-related genes that reduce lifespan.

bioRxiv · Nov 3, 2023 · PreprintCell Biology

Tipifarnib potentiates the antitumor effects of PI3Kα inhibition in PIK3CA- and HRAS-dysregulated HNSCC via convergent inhibition of mTOR activity

A. E. Smith, S. Chan, Z. Wang, A. McCloskey, Q. Reilly, J. Z. Wang, H. V. Patel, K. Koshizuka, H. S. Soifer, L. Kessler, A. Dayoub, V. Villaflor, D. Adkins, J. Y. Bruce, A. Ho, , S. Malik

This study combines tipifarnib and alpelisib to target PI3K-mTOR and HRAS in HNSCC, showing synergy in mTOR inhibition and clinical potential for R/M HNSCC patients.

bioRxiv · Jan 17, 2023 · PreprintCancer Biology

Collection of triatomines from sylvatic habitats by a Chagas-positive, trained scent-detection canine in Texas, USA

D. Christopher, R. Curtis-Robles, G. L. Hamer, J. Bejcek, A. Saunders, W. Roachell, T. L. Cropper, S. A. Hamer

A trained scent-detection dog increased triatomine detection rates in Texas sylvatic habitats, identifying nymphs and nidicolous locations more efficiently than manual searches.

bioRxiv · Sep 14, 2022 · PreprintEcology

Prophylactic low-dose, bi-weekly benznidazole treatment fails to prevent Trypanosoma cruzi infection in dogs under intense transmission pressure

J. Bustamante, A. Padilla, B. White, L. Auckland, R. Busselman, S. Collins, E. Malcolm, B. Wilson, A. Saunders, S. Hamer, R. L. Tarleton

This study tests low-dose, bi-weekly benznidazole prophylaxis in dogs under high T. cruzi transmission pressure but finds no reduction in new infections.

bioRxiv · Jul 25, 2022Microbiology

CD200R1 promotes IL-17 production by ILC3s, by enhancing STAT3 activation

H. Linley, A. Ogden, S. Jaigirdar, L. Buckingham, J. Cox, M. Priestley, A. Saunders

This study shows CD200R1 promotes IL-17 production by ILC3s through STAT3 activation, and its deficiency reduces psoriasis severity.

bioRxiv · Apr 17, 2022Immunology

Reduced cutaneous CD200:CD200R1 signalling in psoriasis enhances neutrophil recruitment to skin

H. Linley, S. Jaigirdar, K. Mohamed, C. E. Griffiths, A. Saunders

This study shows reduced CD200:CD200R1 signaling in psoriasis skin enhances neutrophil recruitment and inflammation in mouse models.

bioRxiv · Apr 1, 2022 · PreprintImmunology