R. L. Tarleton

Serial "deep-sampling" PCR of fragmented DNA reveals the wide range of Trypanosoma cruzi burden among chronically infected hosts and allows accurate monitoring of parasite load following treatment

This study introduces deep-sampling PCR to detect and quantify T. cruzi parasite load in chronically infected hosts, revealing large variations in parasite levels and enabling treatment monitoring.

Validation of a multiplex microsphere immunoassay for detection of Trypanosoma cruzi antibodies in dogs

This study validates a multiplex microsphere immunoassay for detecting Trypanosoma cruzi antibodies in dogs, showing 100% sensitivity and 96.97% specificity compared to the indirect fluorescent antibody test.

Frequency variation and dose modification of benznidazole administration for the treatment of Trypanosoma cruzi infection in mice, dogs and non-human primates

This study evaluates modified benznidazole dosing schedules in mice, dogs, and non-human primates to improve parasitological cure rates for Trypanosoma cruzi infection.

Prophylactic low-dose, bi-weekly benznidazole treatment fails to prevent Trypanosoma cruzi infection in dogs under intense transmission pressure

This study tests low-dose, bi-weekly benznidazole prophylaxis in dogs under high T. cruzi transmission pressure but finds no reduction in new infections.

High variation in immune responses and parasite phenotypes in naturally acquired Trypanosoma cruzi infection in a captive non-human primate breeding colony in Texas, USA

The paper investigates immune responses and parasite phenotypes in naturally infected cynomolgus macaques, revealing diverse parasite genetic types and immune profiles despite uniform housing conditions.

Strain-specific genome evolution in Trypanosoma cruzi, the agent of Chagas disease

This study uses long-read sequencing and proximity ligation mapping to analyze genetic diversity in two T. cruzi strains, revealing mechanisms of gene amplification, dispersion, and recombination that contribute to immune evasion and genome evolution.

Spontaneous dormancy protects Trypanosoma cruzi during extended drug exposure

This study shows Trypanosoma cruzi can enter a dormant state that protects it from prolonged drug exposure, allowing it to re-emerge and cause infection.