B. Wilson

Small molecule screen identifies non-catalytic USP3 chemical handle

The paper identifies a small molecule ligand for the ZnF-UBD of USP3 with a KD of 14 µM, which could serve as a starting point for developing DUBTACs.

Extending the dynamic range of biomarker quantification through molecular equalization

This paper introduces a method to extend the dynamic range of biomarker quantification by equalizing molecular signals, achieving seven orders of magnitude in a single undiluted sample.

Significantly amplified photoacoustic effect for silica-coated gold nanoparticles by interface heat transfer mechanisms

This study demonstrates a 4-fold photoacoustic amplification in silica-coated gold nanoparticles using picosecond laser excitation, attributed to interface heat transfer mechanisms.

Prophylactic low-dose, bi-weekly benznidazole treatment fails to prevent Trypanosoma cruzi infection in dogs under intense transmission pressure

This study tests low-dose, bi-weekly benznidazole prophylaxis in dogs under high T. cruzi transmission pressure but finds no reduction in new infections.

Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families

The paper uses proximity labeling to identify protein complexes associated with Rab4, Rab11a, and Rab25 in cancer cells, revealing their roles in endocytic recycling and cell migration.

Wide-Field Multicontrast Nonlinear Microscopy for Histopathology

The paper develops a multicontrast microscope for histopathology imaging, optimizing conditions for H&E stained slides and analyzing collagen organization.

Pre-equilibrium biosensors: A new approach towards rapid and continuous molecular measurements

This paper introduces a pre-equilibrium biosensor method to rapidly and sensitively measure ligand concentrations before equilibrium, demonstrating its application to continuous insulin monitoring.

A tumor suppressive long noncoding RNA, DRAIC, inhibits protein translation and induces autophagy by activating AMPK

The paper identifies DRAIC, a tumor suppressive lncRNA, which inhibits NF-kB and activates AMPK-mTOR pathways to suppress cancer progression.

Nanoparticle fragmentation at solid state under single picosecond laser pulse stimulation

This study shows that picosecond laser pulses cause gold nanoparticle fragmentation that differs from known mechanisms, occurring below melting point and producing a bimodal size distribution.

Translation factor mRNA granules direct protein synthetic capacity to regions of polarized growth

The paper shows that translation factor mRNAs form granules transported to yeast daughter cells, enhancing protein synthesis at growth tips.