Author

A. Alon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3 Biophysics· 1 Immunology· 1 Microbiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Approach:benchmark study· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Kruse· 3 shared J. Lyu· 3 shared B. K. Shoichet· 2 shared M. J. O'Meara· 2 shared T. A. Tummino· 2 shared A. C. Kruse· 1 shared A. Fischer· 1 shared A. G. Green· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersPharmacology & Toxicology

A. Kruse

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

AlphaFold2 structures template ligand discovery

J. Lyu, N. Kapolka, R. Gumpper, A. Alon, L. Wang, M. Jain, X. Alvarez, K. Sakamoto, Y. Kim, J. DiBerto, K. Kim, T. Tummino, S. Huang, J. Irwin, O. Tarkhanova, , B. Roth

This study evaluates AlphaFold2 models for ligand discovery, finding they perform similarly to experimental structures despite conformational differences, and identify potent agonists for the 5-HT2A receptor.

bioRxiv · Dec 20, 2023 · PreprintPharmacology & Toxicology

Antagonistic nanobodies reveal mechanism of GSDMD pore formation and unexpected therapeutic potential

L. D. J. Schiffelers, S. Normann, S. C. Binder, E. Hagelauer, A. Kopp, A. Alon, M. Geyer, H. L. Ploegh, F. I. Schmidt

This study uses nanobodies to reveal GSDMD pore formation mechanism and shows their therapeutic potential in preventing pyroptosis.

bioRxiv · Apr 20, 2023Immunology

Combined drought resistance strategies and the hydraulic limit in co-existing Mediterranean woody species

A. Alon, S. Cohen, R. Burlett, U. Hochberg, V. Lukyanov, I. Rog, T. Klein, H. Cochard, S. Delzon, R. David-Schwartz

The paper examines drought resistance strategies in Mediterranean woody species, finding interspecific variation in hydraulic and osmotic traits that lead to narrow hydraulic safety margins and risk of mortality near their distribution's dry margin.

bioRxiv · Apr 1, 2022 · PreprintPlant Biology

Dormant spores sense amino acids through the B subunits of their germination receptors

L. Artzi, A. Alon, K. P. Brock, A. G. Green, A. Tam, F. H. Ramirez-Guadiana, D. Marks, A. Kruse, D. Z. Rudner

The paper identifies GerAB as the L-alanine sensor in spores, showing mutations in its ligand-binding pocket impair germination and substitutions enable response to other amino acids.

bioRxiv · Oct 28, 2021Microbiology

Crystal structures of the σ2 receptor template large-library docking for selective chemotypes active in vivo

A. Alon, J. Lyu, J. M. Braz, T. A. Tummino, V. Craik, M. J. O'Meara, C. M. Webb, D. S. Radchenko, Y. S. Moroz, X.-P. Huang, Y. Liu, B. L. Roth, J. J. Irwin, A. I. Basbaum, B. K. Shoichet, A. C. Kruse

This study uses crystal structures of the σ2 receptor to dock and screen a large library, identifying new chemotypes with high affinity and selectivity for the receptor.

bioRxiv · Apr 29, 2021Pharmacology & Toxicology

Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2

T. A. Tummino, V. V. Rezelj, B. Fischer, A. Fischer, M. J. O'Meara, B. Monel, T. Vallet, Z. Zhang, A. Alon, H. R. O'Donnell, J. Lyu, H. Schadt, K. M. White, N. J. Krogan, L. Urban, , B. K. Shoichet

bioRxiv · Mar 23, 2021 · PreprintPharmacology & Toxicology

Live cell single molecule tracking and localization microscopy of bioorthogonally labeled plasma membrane proteins

A. I. König, R. Sorkin, A. Alon, D. Nachmias, K. Dhara, G. Brand, O. Yifrach, Y. Roichman, E. Arbely, N. Elia

The paper demonstrates the use of genetic code expansion and bioorthogonal chemistry for live-cell single molecule tracking and localization microscopy of plasma membrane proteins, showing improved resolution and dynamics analysis.

bioRxiv · Jan 12, 2020Biophysics