Immunosuppressive tumor microenvironment of osteosarcoma
A. M. Taylor, J. Sheng, P. K. S. Ng, J. M. Harder, P. Kumar, J. Y. Ahn, Y. Cao, A. M. Dzis, N. L. Jillette, A. Goodspeed, A. Bodlak, Q. Wu, M. S. Isakoff, J. George, J. D. S. Grassman, , C. C. Lau
This study identifies immunosuppressive mechanisms in osteosarcoma using single-cell and spatial transcriptomics, revealing interactions between MDSCs, T-cells, and tumor cells that promote an immunosuppressive microenvironment.
bioRxiv · Nov 1, 2023Cancer Biology