Author

A. Ferrena

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

D. Zheng· 4 shared H. Borjihan· 3 shared H. Zhao· 3 shared J. Wang· 3 shared R. Yang· 3 shared B. Hoang· 2 shared D. Geller· 2 shared E. Schwartz· 2 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

D. Zheng

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4 papers

Recent·Most cited

Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis

X. Zhuang, Q. Wang, S. Joost, A. Ferrena, D. T. Humphreys, Z. LI, M. Blum, K. Bastl, S. Ding, Y. Landais, Y. Zhan, Y. Zhao, R. Chaligne, J.-H. Lee, S. E. Carrasco, , T. Tammela

This study shows aging reduces lung stem cell function and suppresses lung cancer by inducing iron deficiency through the NUPR1-lipocalin-2 pathway.

bioRxiv · Jun 23, 2024 · PreprintCancer Biology

Comprehensive single cell transcriptomics analysis of murine osteosarcoma uncovers Skp2 function in metastasis, genomic instability and immune activation and reveals additional target pathways

A. Ferrena, R. Zhang, J. Wang, X. Y. Zheng, B. Goker, H. Borjihan, S.-S. Chae, Y. Lo, H. Zhao, E. Schwartz, D. Loeb, R. Yang, D. Geller, D. Zheng, B. Hoang

This study uses scRNA-seq to analyze murine osteosarcoma models and identifies Skp2's role in metastasis, genomic instability, and immune activation, revealing potential therapeutic targets.

bioRxiv · Jun 4, 2024 · PreprintCancer Biology

Targeted inhibition of SCF-SKP2 confers anti-tumor activities resulting in a survival benefit in osteosarcoma

J. Wang, A. Ferrena, S. Singh, V. Viscarret, W. Al-Hardan, O. Aldahamsheh, H. Borjihan, A. Singla, S. Yaguare, J. Tingling, X. Zi, Y. Lo, R. Gorlick, E. L. Schwartz, H. Zhao, , B. H. Hoang

This study shows that inhibiting SKP2 in osteosarcoma reduces tumor growth and improves survival, suggesting it as a potential therapeutic target.

bioRxiv · May 13, 2023 · PreprintCancer Biology

SKP2 knockout in Rb1/p53 deficient mouse models of osteosarcoma induces immune infiltration and drives a transcriptional program with a favorable prognosis

A. Ferrena, J. Wang, R. Zhang, B. Karadal-Ferrena, W. al-Hardan, S. Singh, H. Borjihan, E. Schwartz, H. Zhao, R. Yang, D. Geller, B. Hoang, D. Zheng

This study shows SKP2 knockout in osteosarcoma mouse models increases immune infiltration and correlates with improved patient survival.

bioRxiv · May 9, 2023Cancer Biology