B. L. Stoddard

Design of four component T=4 tetrahedral, octahedral, and icosahedral protein nanocages through programmed symmetry breaking

The paper designs T=4 protein nanocages with tetrahedral, octahedral, and icosahedral symmetries using pseudo-symmetrization of trimeric building blocks, resulting in structures with distinct subunits and interfaces.

Stepwise design of pseudosymmetric protein hetero-oligomers

The paper introduces a method to design pseudosymmetric protein hetero-oligomers by redesigning symmetric homo-oligomers and recombining them to form new hetero-oligomers with high structural specificity.

Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge

This study evaluates a nanoparticle vaccine displaying EBV gH/gL, showing it protects humanized mice against lethal EBV challenge, while monomeric gH/gL does not.

The structural basis of mRNA recognition and binding by eukaryotic pseudouridine synthase PUS1

This study determines the crystal structure of yeast PUS1 bound to an RNA target, revealing how it recognizes and modifies mRNA and tRNA substrates.

Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme visualized by CryoEM

This study visualizes how a bifunctional restriction-modification enzyme coordinates DNA methylation and cleavage using CryoEM, revealing the structural basis for its dual function.

The novel anti-CRISPR AcrIIA22 relieves DNA torsion in target plasmids and impairs SpyCas9 activity

The paper identifies AcrIIA22 as an anti-CRISPR protein that inhibits SpyCas9 by relieving DNA torsion in plasmids.

Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome

The paper identifies potent Cas9 inhibitors from human microbiomes using functional metagenomics, discovering AcrIIA11 as a strong inhibitor with a novel mechanism.