MICROGLIAL CELL EXPRESSION OF THE TYPE 2 CANNABINOID RECEPTOR REGULATES IMMUNE-MEDIATED NEUROINFLAMMATION
A. Moe, A. Rayasam, G. Sauber, R. Shah, C. Y. Yuan, A. Szabo, B. Moore, M. Colonna, W. Cui, J. Romero, A. Zamora, C. Hillard, W. Drobyski
This study shows that CB2R on microglia drives neuroinflammation in GVHD by promoting T cell activation and neuronal death, and that targeting CB2R reduces inflammation without worsening systemic GVHD.
bioRxiv · Aug 10, 2023 · PreprintImmunology