Author

B. Roth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:benchmark study· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:flow cytometry· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Alon· 1 shared A. Kruse· 1 shared A. Moroni· 1 shared B. Jakob· 1 shared B. Shoichet· 1 shared C. Fournier· 1 shared D. H. Tandl· 1 shared F. Roedel· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Alon

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2 papers

Recent·Most cited

AlphaFold2 structures template ligand discovery

J. Lyu, N. Kapolka, R. Gumpper, A. Alon, L. Wang, M. Jain, X. Alvarez, K. Sakamoto, Y. Kim, J. DiBerto, K. Kim, T. Tummino, S. Huang, J. Irwin, O. Tarkhanova, , B. Roth

This study evaluates AlphaFold2 models for ligand discovery, finding they perform similarly to experimental structures despite conformational differences, and identify potent agonists for the 5-HT2A receptor.

bioRxiv · Dec 20, 2023 · PreprintPharmacology & Toxicology

X-ray Irradiation activates immune response in human T-lymphocytes by eliciting a Ca2+ signaling cascade

G. Thiel, D. H. Tandl, T. Sponagel, S. Fuck, T. Smit, S. Hehlgans, B. Jakob, C. Fournier, F. Roedel, B. Roth, A. Moroni

The paper shows X-ray irradiation triggers a Ca2+ signaling cascade in T-lymphocytes, leading to immune activation through NFAT nuclear translocation.

bioRxiv · Nov 13, 2020Biophysics