Author

X. Alvarez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cell Biology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Organism:non-human primate· 3 Organism:rat· 2 Approach:benchmark study· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

B. F. Keele· 2 shared C. Hallam· 2 shared C. M. Fennessey· 2 shared D. Kaushal· 2 shared H. Staples· 2 shared J. D. Lifson· 2 shared L. Parodi· 2 shared M. Gazi· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersImmunology

B. F. Keele

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Author profile →

7 papers

Recent·Most cited

AlphaFold2 structures template ligand discovery

J. Lyu, N. Kapolka, R. Gumpper, A. Alon, L. Wang, M. Jain, X. Alvarez, K. Sakamoto, Y. Kim, J. DiBerto, K. Kim, T. Tummino, S. Huang, J. Irwin, O. Tarkhanova, , B. Roth

This study evaluates AlphaFold2 models for ligand discovery, finding they perform similarly to experimental structures despite conformational differences, and identify potent agonists for the 5-HT2A receptor.

bioRxiv · Dec 20, 2023 · PreprintPharmacology & Toxicology

Lymphoid tissues contribute to viral clonotypes present in plasma at early post-ATI in SIV-infected rhesus macaques

A. Solis-Leal, N. Boby, S. Mallick, Y. Cheng, F. Wu, G. De La Torre, J. Dufour, X. Alvarez, V. Shivanna, Y. Liu, C. M. Fennessey, J. D. Lifson, Q. Li, B. F. Keele, B. Ling

This study identifies secondary lymphoid tissues as a source of SIV clonotypes detected in plasma early after antiretroviral therapy interruption.

bioRxiv · May 30, 2023 · PreprintImmunology

A tyrosine-based trafficking signal in the simian immunodeficiency virus envelope cytoplasmic domain is strongly selected for in pathogenic SIV infection

S. Lawrence, S. E. Elser, W. Torben, R. V. Blair, B. Pahar, P. P. Aye, F. Schiro, D. Szeltner, L. A. Doyle-Meyers, B. Haggarty, A. O. Jordan, J. Romano, X. Alvarez, D. H. O'Connor, R. W. Wiseman, , J. A. Hoxie

This study shows that a tyrosine-based trafficking signal in SIV Env is strongly selected for during pathogenic infection, as mutations reconstitute endocytosis and polarized sorting signals.

bioRxiv · Mar 31, 2021 · PreprintCell Biology

Lethality of SARS-CoV-2 infection in K18 human angiotensin converting enzyme 2 transgenic mice

F. Oladunni, J.-G. Park, P. Pino Tamayo, O. Gonzalez, A. Ahkter, A. Allue Guardia, A. Olmo-Fontanez, S. Gautam, A. Garcia Vilanova, C. Ye, K. Chiem, C. Headley, V. Dwivedi, L. Parodi, K. Alfson, , J. B. Torrelles

This study demonstrates that K18 hACE2 transgenic mice are susceptible to SARS-CoV-2 infection, exhibit cytokine and chemokine storms, and serve as a model for studying viral pathogenesis and therapeutic development.

bioRxiv · Jul 18, 2020Microbiology

SARS-CoV-2 infection leads to acute infection with dynamic cellular and inflammatory flux in the lung that varies across nonhuman primate species

D. K. Singh, S. R. Ganatra, B. Singh, J. Cole, K. J. Alfson, E. Clemmons, M. Gazi, O. Gonzalez, R. Escabedo, T.-H. Lee, A. Chatterjee, Y. Goez-Gazi, R. Sharan, R. Thippeshappa, M. Gough, , M

This study compares SARS-CoV-2 infection in three nonhuman primate species, showing varied disease progression and immune responses.

bioRxiv · Jun 5, 2020Immunology

Control of Mycobacterium tuberculosis Infection in Lungs is Associated with Recruitment of Antigen-Specific Th1 and Th17 cells Co-expressing CXCR3 and CCR6.

U. Shanmugasundaram, A. N. Bucsan, S. R. Ganatra, C. Ibegbu, M. Quezada, R. V. Blair, X. Alvarez, V. Velu, D. Kaushal, J. Rengarajan

This study identifies that Mtb-specific Th1 and Th17 cells co-expressing CXCR3 and CCR6 are critical for immune control in lung compartments during asymptomatic TB infection.

bioRxiv · Mar 9, 2020Immunology

Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys

C. S. Nelson, D. V. Cruz, D. Tran, K. M. Bialas, L. Stamper, H. Wu, M. Gilbert, R. Blair, X. Alvarez, H. Itell, M. Chen, A. Deshpande, F. Chiuppesi, F. Wussow, D. J. Diamond, , S. R. Permar

This study shows that preexisting antibodies can prevent congenital cytomegalovirus infection in monkeys by blocking placental transmission.

bioRxiv · Apr 15, 2017Immunology