Heterozygosity for Crohn's Disease Risk Allele of ATG16L1 Protects against Bacterial Infection
X. Yao, E. Rudensky, P. K. Martin, E. E. Zwack, Z. He, G. C. Furtado, S. A. Lira, V. J. Torres, B. Shopsin, K. Cadwell
The paper shows that heterozygosity for the ATG16L1 T300A allele protects against Salmonella infection, while homozygosity increases susceptibility.
bioRxiv · Feb 22, 2024 · PreprintImmunology