X. Yao

CRISPR/Cas14a Combined with RPA for Visual Detection of Marek's Disease Virus

The paper develops a rapid, instrument-free, and specific nucleic acid detection method for Marek's Disease Virus (MDV-1) using CRISPR/Cas14a and RPA, achieving a detection limit of 24.6 copies/L and 100% accuracy in clinical samples.

Sex-dependent gastrointestinal colonization resistance to MRSA is microbiota and Th17 dependent

This study shows female mice clear MRSA from the gut faster than males, relying on gut microbiota and Th17 cells, while ovariectomy reduces this resistance.

PIP-Seq identifies novel heterogeneous lung innate lymphocyte population activation after combustion product exposure

The paper introduces PIP-Seq to study lung ILC activation after exposure to environmental toxins, identifying novel ILC subsets and activation pathways.

Multi-step engineered adeno-associated virus enables whole-brain mRNA delivery

This paper develops a system to package mRNAs into AAVs, enabling efficient whole-brain mRNA delivery in mice.

scRNA-seq revealed the rules for CDR3 length pairing in TCR beta and alpha chains and BCR heavy and light chains in human and mice

This study uses scRNA-seq to analyze CDR3 length pairing rules in TCR and BCR chains across human and mouse cells, revealing species-specific differences and increased plasticity in humans.

Development of a Two-Leaf Photosynthetic Model Sensitive to Chlorophyll and Its Coupling with a Wheat Growth Model

This study develops a two-leaf photosynthetic model sensitive to chlorophyll and couples it with a wheat growth model to better understand the effects of nitrogen dynamics and diffuse light on photosynthesis.

A double-negative prostate cancer subtype is vulnerable to SWI/SNF-targeting degrader molecules

This study identifies a SWI/SNF-targeting therapy effective against a double-negative prostate cancer subtype, showing it reduces viability in both AR-dependent and WNT-dependent models.

Heterozygosity for Crohn's Disease Risk Allele of ATG16L1 Protects against Bacterial Infection

The paper shows that heterozygosity for the ATG16L1 T300A allele protects against Salmonella infection, while homozygosity increases susceptibility.

The EGF/EGFR-YAP1/TEAD2 axis-mediated BRAF inhibitor vemurafenib resistance upregulates STIM1 in melanoma

This study identifies the EGF/EGFR-YAP1/TEAD2 axis as a mechanism by which vemurafenib resistance upregulates STIM1 in melanoma.

High-throughput structure determination of an intrinsically disordered protein using cell-free protein crystallization

This paper develops a cell-free protein crystallization method to determine the structure of an intrinsically disordered protein and identifies key residues stabilizing its helical conformation.

The mitochondrial deoxyguanosine kinase is required for female fertility in mice

This study shows that Dguok knockout causes female infertility in mice by impairing ovarian development, oocyte maturation, and mitochondrial function.

Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation

This study identifies RNF146 as an E3 ubiquitin ligase that degrades TEAD proteins via the proteasome, showing that pharmacological induction of TEAD ubiquitination can suppress YAP/TAZ-driven cancer growth.

A telomere-to-telomere genome assembly of Zhonghuang 13, a widely-grown soybean variety from the original center of Glycine max

This paper presents the first telomere-to-telomere genome assembly of the soybean cultivar Zhonghuang 13, resolving gaps and identifying novel genes and structural variations.

A muscle hypertrophy-derived myokine reprograms the stromal vascular fractions differentiation towards thermogenic adipocytes in subcutaneous adipose tissue

This study identifies Thbs4 as a muscle-derived myokine that promotes the conversion of white to beige adipocytes in subcutaneous adipose tissue, improving metabolic health and protecting against high-fat diet-induced disorders.

Oral immunization with rVSV bivalent vaccine elicits protective immune responses, including ADCC, against both SARS-CoV-2 and Influenza A viruses

A KDELR-mediated ER retrieval system guides the signaling pathways of UPR and AMPK to maintain cellular homeostasis

This study shows that the KDELR/Erd2-mediated ER retrieval system regulates UPR and AMPK signaling to maintain cellular homeostasis by affecting mitochondrial respiration and ROS levels.

Biomaterial based implants caused remote liver fatty deposition through activated blood-derived Kupffer cells

Abdominal biomaterial implantation induces remote organ fatty deposition via activated blood-derived Kupffer cells.

Landscape of IGH germline genes of Chiroptera and the pattern of Rhinolophus affinisbat IGH CDR3 repertoire

This study annotates IGH germline genes in three bat species and analyzes the CDR3 repertoire of Rhinolophus affinis, revealing unique immunological features that may explain asymptomatic viral infections in bats.

Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection.

The paper identifies high frequency naive T cell precursors that drive rapid T cell responses during early SARS-COV-2 and LCMV infections.

Structural insights into AT-rich DNA recognition by SALL family proteins

The paper presents crystal structures of SALL family proteins bound to AT-rich DNA, revealing their recognition mechanism and functional importance in cell fate control.

SARS-CoV-2 mutations affect proteasome processing to alter CD8+ T cell responses

The paper investigates how mutations in flanking regions of SARS-CoV-2 nucleoprotein epitopes affect proteasome processing and CD8+ T cell responses, finding some mutations reduce responses while others enhance them.

Formulation of substrates with agricultural and forestry wastes for Camellia oleifera Abel seedling cultivation

The paper evaluates five compost-based substrates for Camellia oleifera seedling cultivation, finding that a specific combination yields optimal growth and survival rates.

Development and Characterization of Recombinant Vesicular Stomatitis Virus (rVSV)-based Bivalent Vaccine Against COVID-19 Delta Variant and Influenza Virus

This study develops and tests a bivalent rVSV vaccine targeting SARS-CoV-2 Delta and influenza, showing strong immune responses and protection in animal models.

A new early-branching armoured dinosaur from the Lower Jurassic of southwestern China

This paper describes a new early-branching armoured dinosaur from the Lower Jurassic of China, providing insights into the early diversification of thyreophorans.

SARS-CoV-2 Delta Spike Protein Enhances the Viral Fusogenicity and Inflammatory Cytokine Production

This study shows that the Delta variant's spike protein enhances viral entry, cell fusion, and inflammatory cytokine production in immune cells.

High Resolution Nanostructure with Two-stages of Exponential Energy Dissipation at the Ultrathin Osteochondral Interface Tissue of Human Knee Joint

The paper identifies an ultrathin calcified region in human knee osteochondral interface tissue with two-layered micro-nano structures and exponential modulus increase, enhancing energy dissipation and fatigue resistance.

Development and characterization of influenza M2 ectodomain and/or HA stalk-based DC-targeting vaccines for different influenza infections

This study develops and tests DC-targeting influenza vaccines based on EboGP domains, showing they induce strong antibody responses and protect mice against H1N1 and H3N2 influenza.

Diterpenoid Vinigrol activates ATF4/DDIT3-mediated PERK/eIF2 arm of unfolded protein response to drive breast cancer cell death

This study identifies Vinigrol as a broad-spectrum anti-cancer agent that activates the PERK/eIF2 arm of the UPR via ATF4/DDIT3 to induce breast cancer cell death.

Gastric cancer derived exosomes induce peritoneal mesothelial cell EMT through TGF-β1/Smads pathway to promote peritoneal metastasis

This study shows GC-derived exosomes induce EMT in peritoneal mesothelial cells via TGF-β1/Smads pathway, enhancing GC cell migration and adhesion.

Integrative Omics Reveals Subtle Molecular Perturbations Following Ischemic Conditioning in a Porcine Kidney Transplant Model

This study uses integrative omics to detect subtle molecular changes in porcine kidneys after remote ischemic conditioning, finding reduced inflammation and potential fibrosis markers.