Author

G. Putzel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 4 Organism:bacteria (other)· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Pironti· 5 shared B. Shopsin· 4 shared V. J. Torres· 4 shared C. Zhou· 3 shared M. Podkowik· 3 shared J. Chen· 2 shared K. Cadwell· 2 shared R. J. Ulrich· 2 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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5 shared papersMicrobiology

A. Pironti

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Sex-dependent gastrointestinal colonization resistance to MRSA is microbiota and Th17 dependent

A. Lejeune, C. Zhou, D. Ercelen, G. Putzel, X. Yao, A. R. Guy, M. Pawline, M. Podkowik, A. Pironti, V. J. Torres, B. Shopsin, K. Cadwell

This study shows female mice clear MRSA from the gut faster than males, relying on gut microbiota and Th17 cells, while ovariectomy reduces this resistance.

bioRxiv · Jul 17, 2024Immunology

Prophage-encoded methyltransferase drives adaptation of community-acquired methicillin-resistant Staphylococcus aureus

R. J. Ulrich, M. Podkowik, R. Tierce, I. Irnov, G. Putzel, N. Samhadaneh, K. A. Lacey, D. Boff, S. M. Morales, S. Makita, T. K. Karagounis, E. E. Zwack, C. Zhou, R. Kim, K. Drlica, , B. Shopsin

This study identifies a prophage-encoded methyltransferase, pamA, that enhances virulence in CA-MRSA by epigenetically upregulating fnbA, promoting biofilm formation and abscess size.

bioRxiv · Apr 17, 2024 · PreprintMicrobiology

Identification of a proteolysis regulator for an essential enzyme in Mycobacterium tuberculosis

S. C. Kahne, J. H. Yoo, J. Chen, K. Nakedi, L. M. Iyer, G. Putzel, N. M. Samhadaneh, A. Pironti, L. Aravind, D. C. Ekiert, G. Bhabha, K. Y. Rhee, K. H. Darwin

The paper identifies CoaX, a pseudokinase, and pantothenate as regulators of proteasomal degradation of the pantothenate synthesis enzyme PanB in M. tuberculosis.

bioRxiv · Mar 29, 2024 · PreprintMicrobiology

Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress

M. Podkowik, A. I. Perault, G. Putzel, A. Pountain, J. Kim, A. DuMont, E. Zwack, R. J. Ulrich, T. K. Karagounis, C. Zhou, A. F. Haag, J. Shenderovich, G. A. Wasserman, J. Kwon, J. Chen, , B. Shopsin

This study shows that the agr quorum-sensing system in Staphylococcus aureus primes the bacteria to resist oxidative stress by controlling reactive oxygen species, even when the system is not actively activated.

bioRxiv · Jun 8, 2023 · PreprintMicrobiology

Gut microbiome dysbiosis during COVID-19 is associated with increased risk for bacteremia and microbial translocation.

M. Venzon, L. Bernard-Raichon, J. Klein, J. E. Axelrad, C. Zhang, G. A. Hussey, A. P. Sullivan, A. Cassanovas-Massana, M. G. Noval, A. M. Valero-Jimenez, J. Gago, G. Putzel, A. Pironti, E. Wilder, Yale IMPACT Research Team, , J. Schluter

The paper shows that gut microbiome dysbiosis in COVID-19 patients is linked to increased risk of bacteremia and microbial translocation.

bioRxiv · Jul 15, 2021 · PreprintMicrobiology