Author

K.-E. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 5 Assay:structural biology· 2 Organism:Arabidopsis· 1 Approach:biophysical modeling· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

B. M. Collins· 4 shared Q. Guo· 4 shared B. Simonetti· 2 shared J. Sacharz· 2 shared M. Gimenez-Andres· 2 shared M. Healy· 2 shared N. Leneva· 2 shared P. J. Cullen· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersCell Biology

B. M. Collins

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with Retromer

K.-E. Chen, V. A. Tillu, N. Gopaldass, S. R. Chowdhury, N. Leneva, O. Kovtun, J. Ruan, Q. Guo, N. Ariotti, A. Mayer, B. M. Collins

This study investigates how Vps5 and Vps17 SNX-BAR proteins assemble with Retromer, revealing a PL motif in Vps5 that binds Vps29 and is essential for membrane tubule association and cargo recycling.

bioRxiv · Mar 24, 2024Cell Biology

Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complex

Q. Guo, K.-E. Chen, M. Gimenez-Andres, A. Jellett, Y. Gao, B. Simonetti, M. Liu, C. Danson, K. J. Heesom, P. J. Cullen, B. M. Collins

This study defines how FAM21 couples SNX27-Retromer to the WASH complex through motif-based interactions essential for endosomal recycling.

bioRxiv · Aug 15, 2023Cell Biology

The Autophagy Receptor NBR1 Directs the Clearance of Photodamaged Chloroplasts

H.-N. Lee, J. V Chacko, A. Gonzalez Solis, K.-E. Chen, J. A. S. Barros, S. Signorelli, A. Havey Millar, R. D. Vierstra, K. W. Eliceiri, M. S. Otegui

This study shows NBR1 directs microautophagy-mediated clearance of photodamaged chloroplasts in Arabidopsis, independent of canonical autophagy machinery.

bioRxiv · Jan 27, 2023Cell Biology

Structure of the Commander endosomal trafficking complex linked to X-linked intellectual disability/Ritscher-Schinzel syndrome

M. Healy, K. McNally, R. Butkovic, M. Chilton, K. Kato, J. Sacharz, C. McConville, E. Moody, S. Shaw, V. Planelles-Herrero, S. Yadav, J. Ross, U. Borucu, C. Palmer, K.-E. Chen, , P. Cullen

The paper presents the structural model of the Commander endosomal trafficking complex, identifies disease-causing mutations, and reveals its molecular function in trafficking.

bioRxiv · Jan 25, 2023 · PreprintBiochemistry

Mechanistic basis for SNX27-Retromer coupling to ESCPE-1 in promoting endosomal cargo recycling.

B. Simonetti, Q. Guo, M. Gimenez-Andres, K.-E. Chen, E. R. R. Moody, A. J. Evans, C. M. Danson, T. A. Williams, B. M. Collins, P. J. Cullen

This study identifies the molecular mechanism by which SNX27-Retromer interacts with ESCPE-1 to facilitate endosomal cargo recycling, revealing a conserved surface interaction and evolutionary pathway.

bioRxiv · Aug 28, 2021 · PreprintCell Biology

De novo macrocyclic peptides for inhibiting, stabilising and probing the function of the Retromer endosomal trafficking complex

K.-E. Chen, Q. Guo, T. A. Hill, Y. Cui, A. K. Kendall, Z. Yang, R. J. Hall, M. Healy, J. Sacharz, S. J. Norwood, S. Fonseka, B. Xie, R. C. Reid, N. Leneva, R. G. Parton, , B. M. Collins

The paper develops macrocyclic peptides that inhibit, stabilize, and probe the Retromer complex's function, showing high affinity and specificity for different subunits.

bioRxiv · Dec 3, 2020 · PreprintBiochemistry