Lactate Increases Stemness of CD8+ T Cells to Augment Anti-Tumor Immunity
Q. Feng, Z. Liu, X. Yu, T. Huang, J. Chen, J. Wang, J. Wilhelm, S. Li, J. Song, W. Li, Z. Sun, B. Sumer, B. Li, Y.-X. Fu, J. Gao
This study shows lactate enhances CD8+ T cell stemness and improves anti-tumor immunity by increasing Tcf7 expression through histone acetylation.
bioRxiv · Oct 18, 2021Immunology