Author

C. A. LeClair

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:comparative / phylogenetic analysis· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Simeonov· 2 shared D. Tao· 2 shared Y. Fang· 2 shared A. Godfrey· 1 shared A. Thole· 1 shared B. A. Garcia· 1 shared B. O'Keefe· 1 shared C. A. Tristan· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

A. Simeonov

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Comparative analysis of drug-like EP300/CREBBP acetyltransferase inhibitors

M. C. Crawford, D. R. Tripu, S. A. Barritt, Y. Jing, D. Gallimore, S. C. Kales, N. V. Bhanu, Y. Xiong, Y. Fang, K. A. T. Butler, C. A. LeClair, N. P. Coussens, A. Simeonov, B. A. Garcia, C. C. Dibble, J. L. Meier

This study compares the biochemical and biological potencies of three EP300/CREBBP acetyltransferase inhibitors and demonstrates their utility in investigating epigenetic mechanisms.

bioRxiv · May 15, 2023Biochemistry

An approach to rapid distributed manufacturing of broad spectrum anti-viral griffithsin using cell-free systems to mitigate pandemics

S. G. Borhani, M. Z. Levine, L. H. Krumpe, J. Wilson, C. Hendrich, B. O'Keefe, D. Lo, G. Sittampalam, A. Godfrey, R. D. Lunsford, V. Mangalampalli, D. Tao, C. A. LeClair, A. Thole, D. Frey, , G. Rao

This paper describes a cell-free biomanufacturing approach for rapid production of griffithsin, a broad-spectrum antiviral protein, demonstrating its efficacy against SARS-CoV-2 and HIV-1.

bioRxiv · Dec 19, 2022Bioengineering

A Versatile Polypharmacology Platform Promotes Cytoprotection and Viability of Human Pluripotent and Differentiated Cells

Y. Chen, C. A. Tristan, L. Chen, V. Jovanovic, C. Malley, P.-H. Chu, S. Ryu, T. Deng, P. Ormanoglu, D. Tao, Y. Fang, J. Slamecka, C. A. LeClair, S. Michael, C. P. Austin, , I. Singec

The paper identifies a small molecule cocktail, CEPT, that enhances the viability and cytoprotection of human pluripotent and differentiated cells through multi-target drug combinations.

bioRxiv · Oct 22, 2019Cell Biology