T. Deng

On the discovered Cancer Driving Nucleotides (CDNs)-Distributions across genes, cancer types and patients

This study identifies Cancer Driving Nucleotides (CDNs) across cancer types and patients, finding that most remain unidentified and highlights the need for larger sample sizes to improve detection.

The theory of massively repeated evolution and full identifications of Cancer Driving Nucleotides (CDNs)

This study develops a theory to identify Cancer Driving Nucleotides (CDNs) by analyzing mutation recurrence across large cancer datasets, finding that mutations recurring at least three times are likely CDNs.

African Swine Fever Virus Protein B263R Inhibits Autophagy by Promoting Proteasomal Degradation of Beclin1

This study identifies B263R as an ASFV protein that inhibits autophagy by promoting proteasomal degradation of Beclin1, highlighting its role in viral replication and potential therapeutic targets.

ATM-Mediated Translocation of RanBPM Regulates DNA Damage Response by Stabilizing p21 in Non-Small Cell Lung Cancer Cells

The paper identifies a novel mechanism where RanBPM stabilizes p21 via deubiquitination, regulating DNA damage response in NSCLC cells.

Longer mandible or nose? Co-evolution of feeding organs in early elephantiforms

This study investigates the co-evolution of feeding organs in early elephantiforms, finding that feeding function shifted from the mandible to the trunk, enabling proboscideans to expand into new ecological niches.

Genomic underpinnings of convergent adaptation to high altitudes for alpine plants

This study identifies genomic signatures of convergent adaptation to high altitudes in alpine plants by analyzing reference genomes and gene expression profiles.

Survival of mineral-bound peptides into the Miocene

This study shows that peptide sequences from ostrich eggshells survived for 6.5-9 million years, extending the known preservation of ancient proteins to the Miocene.

Reconstructing phylogeny of the hornless rhinoceros Aceratheriinae

This paper presents the first phylogenetic analysis of the subfamily Aceratheriinae, reclassifying tribes and identifying early diverging taxa based on morphological characteristics.

A DNA Replication-Independent Function of the pre-Replication Complex during Cell Invasion in C. elegans

The paper identifies the pre-RC complex as a regulator of cell invasion in C. elegans, independent of its role in DNA replication.

Reversion of antibiotic resistance in drug-resistant bacteria using non-steroidal anti-inflammatory drug benzydamine

This study shows benzydamine enhances tetracycline antibiotics' effectiveness against drug-resistant bacteria by disrupting membrane potential and increasing drug uptake.

Insights into the drivers of radiating diversification in biodiversity hotspots using Saussurea (Asteraceae) as a case

This study examines factors driving radiating diversification in Saussurea using Miocene to present data, finding increased diversification rates linked to climate fluctuations and adaptive traits.

The genome assembly and annotation of Magnolia biondii Pamp., a phylogenetically, economically, and medicinally important ornamental tree species

This paper presents a chromosome-level genome assembly and annotation of Magnolia biondii, revealing insights into its evolutionary history and gene function.

Plastome phylogenomic study of Gentianeae (Gentianaceae): widespread gene tree discordance and its association with evolutionary rate heterogeneity of plastid genes

This study analyzes plastome sequences from Gentianeae to show gene tree discordance and evolutionary rate heterogeneity among plastid genes, suggesting the need for more nuanced phylogenomic approaches.

A Versatile Polypharmacology Platform Promotes Cytoprotection and Viability of Human Pluripotent and Differentiated Cells

The paper identifies a small molecule cocktail, CEPT, that enhances the viability and cytoprotection of human pluripotent and differentiated cells through multi-target drug combinations.

Deubiquitylation and stabilization of p21 by USP11 is critical for cell cycle progression and DNA damage responses

This study identifies USP11 as a deubiquitylase that stabilizes p21, affecting cell cycle progression and DNA damage responses.