Author

C. Coombes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

G. Pruneri· 2 shared L. Magnani· 2 shared M. K. Gardner· 2 shared A. Belfiore· 1 shared A. Hoshino· 1 shared A. J. Nicholls· 1 shared A. Mooneyham· 1 shared A. Ramessur· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCancer Biology

G. Pruneri

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Circulating neutrophils from patients with early breast cancer have distinct subtype-dependent phenotypes

A. Ramessur, B. Ambasager, I. V. Aramburu, F. Peakman, K. Gleason, C. Lehmann, V. Papayannopoulos, C. Coombes, I. Malanchi

This study identifies subtype-specific phenotypic and signaling changes in circulating neutrophils from early breast cancer patients compared to healthy volunteers.

bioRxiv · Apr 19, 2023Cancer Biology

VGLL1 drives therapy resistance in estrogen receptor positive breast cancer

C. Gemma, C. Lai, A. Singh, A. Belfiore, N. Portman, H. Z. Milioli, M. Periyasamy, S. Abuelmaaty, A. J. Nicholls, C. Davies, N. R. Patel, G. Simmons, H. Fan, V. Nguyen, L. Magnani, , S. Ali

This study identifies VGLL1 as a driver of resistance to endocrine therapy in ER+ breast cancer and shows that targeting VGLL1/TEAD interaction can inhibit resistant cell growth.

bioRxiv · Nov 29, 2020Cancer Biology

UNC-45A Weakens and Breaks MT Lattice Independent of its Effect on Non-Muscle Myosin II

M. Bazzaro, J. Habicht, A. Mooneyham, A. Hoshino, M. Shetty, X. Zhang, E. Emmings, Q. Yang, C. Coombes, M. K. Gardner

This study shows UNC-45A weakens and breaks microtubule lattices independently of its effect on non-muscle myosin II, with implications for disease treatment.

bioRxiv · Jun 20, 2020Cell Biology

Structural state recognition facilitates tip tracking of EB1 at growing microtubule ends in cells

T. A. Reid, C. Coombes, S. Mukherjee, R. Goldblum, K. White, S. Parmar, M. McClellan, M. Zanic, N. Courtemanche, M. K. Gardner

The paper shows that EB1 tracks microtubule ends by recognizing structural changes, not just GTP-tubulin binding, using simulations and experiments.

bioRxiv · May 13, 2019Cell Biology

Enhancers mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer.

D. Patten, G. Corleone, B. Gyorffy, E. Erdos, A. Saiakhova, K. Goddard, A. Vingiani, S. Shousha, L. S. Pongor, D. Hadjiminas, G. Schiavon, P. Barry, C. Palmieri, C. Coombes, P. Scacheri, , L. Magnani

This study maps enhancers in luminal breast cancer to reveal phenotypic heterogeneity and its evolutionary dynamics during treatment.

bioRxiv · Sep 26, 2017Cancer Biology