G. Simmons

Central carbon metabolism switching in lytic versus temperate coral reef viral communities

The paper examines viral metabolism in coral reefs, finding that lytic viruses consume central carbon intermediates for virion production, while temperate viruses build them, leading to distinct ecosystem states.

Structure-property machine learning models with predictive capabilities for glycans in food

The paper develops regression models to predict starch properties and sensory texture from structural data in rice, finding structural data better predicts mouthfeel than physical properties.

Administration of vaccine-boosted COVID-19 convalescent plasma to SARS-CoV-2 infected hamsters decreases virus replication in lungs and hastens resolution of the infection despite transiently enhancing disease and lung pathology.

This study shows that vaccine-boosted convalescent plasma reduces SARS-CoV-2 replication in hamsters but temporarily worsens disease and lung pathology.

Human Galectin-9 Potently Enhances SARS-CoV-2 Replication and Inflammation in Airway Epithelial Cells

This study shows that galectin-9 enhances SARS-CoV-2 replication and inflammation in airway epithelial cells by promoting viral entry and activating pro-inflammatory pathways.

Differential and defective expression of Koala Retrovirus indicate complexity of host and virus evolution

This study identifies defective KoRV variants in koalas previously thought to be KoRV-free, suggesting historical exposure and potential protective effects against infectious KoRV.

In situ Alphavirus Assembly and Budding Mechanism Revealed by Cellular CryoET

This study uses cryoET to reveal the in situ assembly and budding mechanism of CHIKV, showing spike-driven particle formation and NAb inhibition of spike-spike interactions.

Early post-infection treatment of SARS-CoV-2 infected macaques with human convalescent plasma with high neutralizing activity reduces lung inflammation

This study treats SARS-CoV-2 infected macaques with high-titer convalescent plasma, showing reduced lung inflammation without affecting virus replication.

Distinct cellular immune signatures in acute Zika virus infection are associated withhigh or low persisting neutralizing antibody titers

The paper uses mass cytometry to identify immune cell signatures in acute ZIKV infection that predict high or low neutralizing antibody titers 6 months post-infection.

Thiol drugs decrease SARS-CoV-2 lung injury in vivo and disrupt SARS-CoV-2 spike complex binding to ACE-2 in vitro

Thiol drugs inhibit SARS-CoV-2 infection in vitro and reduce lung injury in vivo, supporting their potential as COVID-19 treatments.

VGLL1 drives therapy resistance in estrogen receptor positive breast cancer

This study identifies VGLL1 as a driver of resistance to endocrine therapy in ER+ breast cancer and shows that targeting VGLL1/TEAD interaction can inhibit resistant cell growth.

Antigenicity, stability, and reproducibility of Zika reporter virus particles for long-term applications

This study validates ZIKV reporter virus particles (RVPs) as stable, reproducible, and antigenically identical to live virus for large-scale neutralization assays and vaccine development.

Distinct SARS-CoV-2 Antibody Reactivity Patterns in Coronavirus Convalescent Plasma Revealed by a Coronavirus Antigen Microarray

This study uses a coronavirus antigen microarray to identify distinct antibody reactivity patterns in SARS-CoV-2 convalescent plasma, showing high concordance with existing assays and revealing clusters with potential implications for treatment efficacy.

Human IFITM3 restricts Chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteraction

This study shows IFITM3 restricts CHIKV and MAYV infection and is counteracted by these viruses, with a variant showing similar antiviral activity to wild-type.

A 3.4-A cryo-EM structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles

The paper presents a 3.4-A cryo-EM structure of the human coronavirus NL63 spike trimer from vitrified virus particles, revealing structural differences from SARS-CoV-2.

Capturing and Recreating Diverse Antibody Repertoires as Multivalent Recombinant Polyclonal Antibody Drugs

This paper demonstrates a technology to capture and recreate diverse antibody repertoires as multivalent recombinant drugs, showing applications against SARS-CoV-2, Zika virus, and graft-versus-host disease.

Analysis of SARS-CoV-2 Antibodies in COVID-19 Convalescent Blood using a Coronavirus Antigen Microarray

This paper validates a coronavirus antigen microarray to distinguish SARS-CoV-2 convalescent blood from pre-pandemic controls, showing improved discrimination with spike and nucleoprotein antigens.

Reduced Plasma Ascorbic Acid Levels in Recipients of Myeloablative Conditioning & Hematopoietic Cell Transplantation

This study measures ascorbic acid levels in HCT patients post-MAC and finds reduced levels persisting longer in allogeneic recipients.

Identification of stable reference genes for quantitative PCR in koalas

This study identifies the most stable reference genes for quantitative PCR in koala lymph node tissues across two populations using multiple statistical methods.