Author

K. Luk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:CITE-seq· 1

Frequent Co-Authors

S. Wolfe· 2 shared A. Desai· 1 shared A. Guilherme· 1 shared C. Haynes· 1 shared E. J. Sontheimer· 1 shared E. Mintzer· 1 shared E. Tsagkaraki· 1 shared F. Henriques· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

S. Wolfe

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Global profiling of human blood ILC subtypes reveals that NK cells produce homeostatic cytokine amphiregulin and sheds light on HIV-1 pathogenesis

Y. Wang, L. Lifshitz, N. Silverstein, E. Mintzer, K. Luk, P. StLouis, M. Brehm, S. Wolfe, S. Deeks, J. Luban

This study identifies NK cell production of amphiregulin in human blood ILCs and links it to HIV-1 pathogenesis through cytokine signaling and immune cell dynamics.

bioRxiv · Apr 20, 2021 · PreprintImmunology

CRISPR-enhanced human adipocyte 'browning' as cell therapy for metabolic disease

E. Tsagkaraki, S. Nicoloro, T. De Souza, J. Solivan-Rivera, A. Desai, Y. Shen, M. Kelly, A. Guilherme, F. Henriques, R. Ibraheim, N. Amrani, K. Luk, S. Maitland, R. H. Friedline, L. Tauer, , M. P. Czech

This paper uses CRISPR to enhance browning of human adipocytes, improving metabolic health in mice without immunogenic Cas9 exposure.

bioRxiv · Oct 13, 2020Bioengineering

mtDNA replication in dysfunctional mitochondria promotes deleterious heteroplasmy via the UPRmt

Q. Yang, P. Liu, N. Anderson, T. Shpilka, Y. Du, N. Uma Naresh, K. Luk, J. Lavelle, R. Zeinert, P. Chien, S. Wolfe, C. Haynes

The paper shows ATFS-1 promotes {Delta}mtDNA replication by recruiting POLG, while LONP-1 inhibition increases wildtype mtDNA binding and improves heteroplasmy ratio and OXPHOS function.

bioRxiv · Sep 1, 2020 · PreprintCell Biology