J. Lieberman

NOP16 is a histone mimetic that regulates Histone H3K27 methylation and gene repression

This study identifies NOP16 as a histone mimic that regulates H3K27 methylation and gene repression, showing its role in breast cancer progression.

ROS-dependent palmitoylation is an obligate licensing modification for GSDMD pore formation

This study identifies palmitoylation as a required modification for GSDMD pore formation, showing that ROS induces this modification and is essential for membrane translocation and cell death.

Palmitoylation of gasdermin D directs its membrane translocation and pore formation in pyroptosis

The paper identifies palmitoylation of GSDMD at Cys191/Cys192 as essential for its membrane translocation and pore-forming activity in macrophages.

The NK receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells

This study identifies ecto-calreticulin as the ligand for the NKp46 receptor, showing it mediates NK cell recognition and killing of ER-stressed cells and tumors.

Inflammasome activation in infected macrophages drives COVID-19 pathology

This study shows SARS-CoV-2 infection of human macrophages drives COVID-19 pathology through inflammasome activation, leading to inflammation and pyroptosis, but also enabling viral release.

Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes

This study develops and tests human embryonic stem cell-derived chondrocytes for long-term repair of porcine articular cartilage, showing improved functionality compared to current methods.

Multimeric nanobodies from camelid engineered mice and llamas potently neutralize SARS-CoV-2 variants

This paper isolates and characterizes nanobodies from camelids and engineered mice that neutralize SARS-CoV-2 variants through conserved epitopes and multimeric avidity.

Cell lineage as a predictor of immune response in neuroblastoma

This study identifies cell lineage as a key determinant of immune response in neuroblastoma by analyzing transcriptional signatures from 498 tumors and showing that mesenchymal-like cells are more immunogenic than adrenergic neuron-like cells.

Activation of GSDME compensates for GSDMD deficiency in a mouse model of NLRP3 inflammasomopathy

This study shows that GSDME compensates for GSDMD deficiency in NLRP3 inflammasomopathy, revealing a GSDME-dependent inflammatory pathway and suggesting dual inhibition of GSDMD and GSDME for therapeutic benefit.

Structure of the Mammalian Mediator

This study presents a molecular model of mammalian Mediator complex using cryo-EM, revealing the structure of the previously unresolved Tail module and its interactions with core Mediator.

Tombusvirus p19 captures RNase III-cleaved double-stranded RNAs formed by overlapping sense and antisense transcripts in E. coli

The paper uses p19 to capture RNase III-cleaved dsRNA in E. coli, revealing widespread antisense transcription and its potential role in stress responses.

Identification of pyroptosis inhibitors that target a reactive cysteine in gasdermin D

This paper identifies disulfiram and Bay 11-7082 as pyroptosis inhibitors that covalently modify a conserved cysteine in gasdermin D, thereby blocking pore formation and inflammation.