Author

C. L. Holmes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 5

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Research Focus:cell type annotation· 2 Organism:E. coli· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

M. A. Bachman· 4 shared S. Mason· 3 shared A. E. Wilcox· 2 shared B. S. Moricz· 2 shared H. L. T. Mobley· 2 shared J. Vornhagen· 2 shared L. Unverdorben· 2 shared S. N. Smith· 2 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersMicrobiology

M. A. Bachman

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Type-2 diabetes mellitus enhances Klebsiella pneumoniae pathogenesis

K. Todd, K. Gunter, J. M. Bowen, C. L. Holmes, N. L. Tilston-Lunel, J. Vornhagen

This study shows that type 2 diabetes mellitus enhances Klebsiella pneumoniae pathogenesis by increasing gut colonization and lung infection severity.

bioRxiv · May 31, 2024 · PreprintMicrobiology

Patterns of Klebsiella pneumoniae bacteremic dissemination from the lung

C. L. Holmes, K. G. Dailey, K. Hullahalli, A. E. Wilcox, S. Mason, B. S. Moricz, L. Unverdorben, M. K. Waldor, M. A. Bachman

This study tracks Klebsiella pneumoniae dissemination from the lung using barcoding, revealing two distinct patterns of bacterial spread and their associated host and bacterial factors.

bioRxiv · Apr 3, 2024Microbiology

Fitness Factor Genes Conserved within the Multi-species Core Genome of Gram-negative Enterobacterales Species Contribute to Bacteremia Pathogenesis

H. L. T. Mobley, M. T. Anderson, B. L. Moricz, G. S. Severin, C. L. Holmes, E. N. Ottosen, T. Eichler, S. Gupta, S. Paudel, R. Sinha, S. Mason, S. D. Himpsl, A. N. Brown, M. L. Gaca, C. M. Kiser, , M. A. Bachman

The paper identifies 18 conserved fitness genes in Enterobacterales species that contribute to bacteremia pathogenesis by testing mutants in a mouse model and finding attenuation in multiple organs.

bioRxiv · Mar 18, 2024Microbiology

Klebsiella pneumoniae causes bacteremia using factors that mediate tissue-specific fitness and resistance to oxidative stress

C. L. Holmes, A. E. Wilcox, V. Forsyth, S. N. Smith, B. S. Moricz, L. V. Unverdorben, S. Mason, W. Wu, L. Zhao, H. L. T. Mobley, M. A. Bachman

This study identifies 58 K. pneumoniae genes critical for bloodstream fitness during bacteremia, revealing tissue-specific mechanisms and resistance to oxidative stress.

bioRxiv · Feb 23, 2023 · PreprintMicrobiology

The ADP-heptose biosynthesis enzyme GmhB is a conserved Gram-negative bacteremia fitness factor

C. L. Holmes, S. N. Smith, S. J. Gurczynski, G. B. Severin, L. Unverdorben, J. Vornhagen, H. L. Mobley, M. A. Bachman

This study identifies GmhB as a conserved Gram-negative bacteremia fitness factor that enhances bloodstream survival through LPS-mediated mechanisms, but is dispensable in the lung.

bioRxiv · Mar 8, 2022Microbiology