Author

M. A. Bachman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 10

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 6 Research Focus:cell type annotation· 4 Organism:human· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Organism:E. coli· 2 Research Focus:differential expression· 1

Frequent Co-Authors

H. L. T. Mobley· 4 shared J. Vornhagen· 4 shared S. N. Smith· 4 shared L. Zhao· 3 shared S. Mason· 3 shared V. Forsyth· 3 shared Y. Sun· 3 shared A. Patel· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersMicrobiology

H. L. T. Mobley

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10 papers

Recent·Most cited

Conserved metabolic regulator ArcA responds to oxygen availability, iron limitation, and cell envelope perturbations during bacteremia

A. N. Brown, M. T. Anderson, S. Smith, M. A. Bachman, H. L. T. Mobley

This study identifies ArcA as a conserved metabolic regulator in Gram-negative bacteria during bacteremia, showing its role in adapting to oxygen, iron, and membrane stress.

bioRxiv · Apr 18, 2023Microbiology

Klebsiella pneumoniae causes bacteremia using factors that mediate tissue-specific fitness and resistance to oxidative stress

C. L. Holmes, A. E. Wilcox, V. Forsyth, S. N. Smith, B. S. Moricz, L. V. Unverdorben, S. Mason, W. Wu, L. Zhao, H. L. T. Mobley, M. A. Bachman

This study identifies 58 K. pneumoniae genes critical for bloodstream fitness during bacteremia, revealing tissue-specific mechanisms and resistance to oxidative stress.

bioRxiv · Feb 23, 2023 · PreprintMicrobiology

The Klebsiella pneumoniae ter operon enhances stress tolerance

S. Mason, J. Vornhagen, S. N. Smith, L. A. Mike, H. A. Mobley, M. A. Bachman

This study identifies the ter operon in Klebsiella pneumoniae as a stress tolerance factor, enhancing fitness in the gut and bladder by protecting against environmental stressors.

bioRxiv · Dec 2, 2022 · PreprintMicrobiology

The ADP-heptose biosynthesis enzyme GmhB is a conserved Gram-negative bacteremia fitness factor

C. L. Holmes, S. N. Smith, S. J. Gurczynski, G. B. Severin, L. Unverdorben, J. Vornhagen, H. L. Mobley, M. A. Bachman

This study identifies GmhB as a conserved Gram-negative bacteremia fitness factor that enhances bloodstream survival through LPS-mediated mechanisms, but is dispensable in the lung.

bioRxiv · Mar 8, 2022Microbiology

Measurement of Klebsiella Intestinal Colonization Density to Assess Infection Risk

Y. Sun, A. Patel, J. SantaLucia, E. Roberts, L. Zhao, K. S. Kaye, K. Rao, M. A. Bachman

This study develops a qPCR assay to measure Klebsiella colonization density in rectal swabs and finds that higher density is significantly associated with increased infection risk.

bioRxiv · Feb 16, 2021Microbiology

Gut microbiome features are associated with sepsis onset and outcomes

K. Rao, A. Patel, A. M. Seekatz, C. Bassis, Y. Sun, O. Henig, O. Albin, J. SantaLucia, R. Woods, M. A. Bachman

This study finds that gut microbiome features, including increased Enterococcus and total bacterial abundance, and decreased butyrate-producing bacteria, are associated with sepsis onset and mortality.

bioRxiv · Jan 8, 2021 · PreprintMicrobiology

A systematic analysis of hypermucoviscosity and capsule reveals distinct and overlapping genes that impact Klebsiella pneumoniae fitness

L. A. Mike, A. J. Stark, V. Forsyth, J. Vornhagan, S. N. Smith, M. A. Bachman, H. L. T. Mobley

This study identifies genes affecting capsule and hypermucoviscosity in Klebsiella pneumoniae, showing their integration with central metabolism for bacterial fitness.

bioRxiv · Jun 22, 2020Microbiology

Comparative study of four SARS-CoV-2 Nucleic Acid Amplification Test (NAAT) platforms demonstrates that ID NOW performance is impaired substantially by patient and specimen type.

P. R. Lephart, M. A. Bachman, W. LeBar, S. W. McClellan, K. Barron, L. Schroeder, D. W. Newton

This study compares four SARS-CoV-2 NAAT platforms, finding that ID NOW performs worse than others, especially with nasal swabs and in chronically infected patients.

bioRxiv · Jun 4, 2020Microbiology

A plasmid locus associated with Klebsiella clinical infections encodes a microbiome-dependent gut fitness factor

J. Vornhagen, C. Bassis, S. Ramakrishnan, R. Hein, S. Mason, Y. Bergman, N. Sunshine, Y. Fan, W. Timp, M. C. Schatz, V. B. Young, P. J. Simner, M. A. Bachman

The paper identifies a plasmid-encoded ter operon in Klebsiella pneumoniae that functions as a microbiome-dependent gut fitness factor, enhancing colonization in the presence of specific gut microbiota.

bioRxiv · Feb 26, 2020Microbiology

The Klebsiella pneumoniae citrate synthase gene, gltA, influences site specific fitness during infection

J. Vornhagen, Y. Sun, P. Breen, V. Forsyth, L. Zhao, H. L. T. Mobley, M. A. Bachman

This study identifies the Kp citrate synthase gene gltA as critical for metabolic flexibility during infection, showing organ-specific fitness defects in lung and gut colonization.

bioRxiv · Mar 5, 2019Microbiology