J. Sliz

Assessment of Human Renal Transporter Based Drug-Drug Interactions Using Proximal Tubule Kidney-Chip

This study develops a human Proximal Tubule Kidney-Chip to assess renal transporter-based drug-drug interactions and demonstrates its ability to predict clinical outcomes and clearance values.

Qualifying a human Liver-Chip for predictive toxicology: Performance assessment and economic implications

The paper evaluates a Liver-Chip's ability to predict drug-induced liver injury and estimates its economic impact in pharmaceutical R&D.

A novel Organ-Chip system emulates three-dimensional architecture of the human epithelia and allows fine control of mechanical forces acting on it.

This paper introduces a new Organ-Chip system that emulates the 3D architecture of human epithelia and allows precise control of mechanical forces, demonstrating its feasibility with skin and alveolar epithelial cells.

Liver-Chip: Reproducing Human and Cross-Species Toxicities

The paper designs Liver-Chips for rat, dog, and human to replicate species-specific liver toxicities and predict human relevance.

A robotic platform for fluidically-linked human body-on-chips experimentation

The paper introduces an automated platform for culturing and analyzing human Organ Chips, demonstrating its ability to maintain organ function and predict tracer distribution using a computational model.