L. Leng

Suppression of Plasmodium MIF-CD74 Signaling Protects Against Severe Malaria

This study shows that blocking Plasmodium MIF-CD74 signaling protects against experimental cerebral malaria by preventing antigen presentation to CD8+ T cells.

A novel Organ-Chip system emulates three-dimensional architecture of the human epithelia and allows fine control of mechanical forces acting on it.

This paper introduces a new Organ-Chip system that emulates the 3D architecture of human epithelia and allows precise control of mechanical forces, demonstrating its feasibility with skin and alveolar epithelial cells.

Potential microenvironment of SARS-CoV-2 infection in airway epithelial cells revealed by Human Protein Atlas database analysis

The paper analyzes the Human Protein Atlas database to identify potential key molecules in the airway epithelial cell microenvironment that may facilitate SARS-CoV-2 entry and immune response activation.

Glioblastoma myeloid-derived suppressor cell subsets express differential macrophage migration inhibitory factor receptor profiles that can be targeted to reduce immune suppression

This study identifies differential MIF receptor expression in GBM MDSC subsets and shows targeting M-MDSCs with ibudilast reduces immune suppression.

A robotic platform for fluidically-linked human body-on-chips experimentation

The paper introduces an automated platform for culturing and analyzing human Organ Chips, demonstrating its ability to maintain organ function and predict tracer distribution using a computational model.