J. C. Nawroth

The paper uses 3D spheroids and spatial transcriptomics to identify LAMFs and LECs as key contributors to LAM, with bFGF and VEGF-A as potential therapeutic targets.

The paper develops an in vitro model of PCD using hiPSC-derived airway epithelium that recapitulates disease-specific phenotypes.

The paper shows that ciliated organ designs follow functional constraints, connecting carpet and flame types through lumen diameter and cilia-to-lumen ratio.

The paper shows that spontaneous body wall contractions in Hydra enhance fluid transport, shaping host-microbe associations and modulating microbial spatial distribution.

This study shows that applying airflow and stretch to airway epithelial cultures on a chip accelerates mucociliary maturation and alters cellular composition to better mimic airway biology.

This paper develops a human ALD Liver-Chip to model alcohol-induced liver injury, showing it recapitulates FLD markers and enables multimodal profiling of clinically relevant endpoints.

This paper develops a micro-engineered Airway Lung-Chip model that replicates viral-induced asthma exacerbation features and evaluates immunomodulatory therapies.