D. Foster

Assessing Spns2-dependent S1P Transport as a Prospective Therapeutic Target

This study evaluates a novel S1P transport blocker, SLF80821178, showing efficacy in multiple sclerosis without the cardiac side effects of SRMs, but with less lymphopenia and unchanged lymph S1P levels.

LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants

This paper identifies LY-CoV1404, a potent SARS-CoV-2 neutralizing antibody effective against multiple variants, including Omicron and Delta, due to its conserved epitope and resistance to common mutations.

Xenogeneic Skin Transplantation Promotes Angiogenesis and Tissue Regeneration Through Vitamin D-Activated Trem2+ Macrophages

The paper shows that vitamin D-activated Trem2+ macrophages promote angiogenesis and reduce fibrosis, offering a new strategy for advanced cell therapies in complex wounds.

LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection

LY-CoV555, an anti-spike antibody from a convalescent COVID-19 patient, neutralizes SARS-CoV-2 and protects non-human primates against infection.

Metagenomic Nanopore sequencing of influenza virus direct from clinical respiratory samples

This study uses metagenomic Nanopore sequencing to detect influenza virus in clinical respiratory samples, achieving high sensitivity and complete genome sequencing.

Nanopore metagenomic sequencing of full length human metapneumovirus (HMPV) within a unique sub-lineage

This study uses Nanopore metagenomic sequencing to directly sequence the full-length HMPV genome from a UK patient, identifying a unique genetic group and demonstrating the utility of Nanopore for clinical diagnosis.

MinION Nanopore Sequencing of Multiple Displacement Amplified Mycobacteria DNA Direct from Sputum

This study evaluates the effectiveness of multiple displacement amplification followed by MinION sequencing for detecting Mycobacteria DNA in sputum samples.

Human Herpes Virus 6 (HHV-6) - Pathogen or Passenger? A pilot study of clinical laboratory data and next generation sequencing

This study examines HHV-6 prevalence in clinical samples using PCR and NGS, finding 33% positivity in hematology patients and 20% detection via NGS in CSF and respiratory samples.

Real-time analysis of nanopore-based metagenomic sequencing from orthopaedic device infection

This paper compares metagenomic sequencing using Illumina MiSeq and Oxford Nanopore MinION platforms for diagnosing prosthetic joint infections, demonstrating a real-time analysis pipeline for rapid bacterial detection.

Molecular diagnosis of orthopaedic device infection direct from sonication fluid by metagenomic sequencing

This study shows metagenomic sequencing of sonication fluid can accurately diagnose prosthetic joint infections with high sensitivity and specificity.