M. Wright

First endangered black-footed ferrets, Mustela nigripes, cloned for genetic rescue

Researchers cloned an endangered black-footed ferret using cross-species somatic cell nuclear transfer, producing three healthy kits to aid genetic rescue.

BrainLine: An Open Pipeline for Connectivity Analysis of Heterogeneous Whole-Brain Fluorescence Volumes

BrainLine processes whole-brain fluorescence images through registration, segmentation, and analysis using a feedback-based training approach.

CryoEM reveals unprecedented binding site for NaV1.7 inhibitors enabling rational design of potent hybrid inhibitors

This study uses cryo-EM to reveal a new binding site for NaV1.7 inhibitors, enabling the design of hybrid inhibitors with improved selectivity and properties.

Injectable polymer-nanoparticle hydrogel for the sustained intravitreal delivery of bimatoprost

This paper develops an injectable polymer-nanoparticle hydrogel for sustained intravitreal delivery of bimatoprost, showing prolonged drug release and minimal inflammation in rabbits.

Liver Endothelium Microenvironment Promotes HER3-mediated Cell Growth in Pancreatic ductal adenocarcinoma

This study shows liver endothelial cells promote PDAC growth via HER3-AKT signaling, suggesting HER3-targeted therapies for HER3-positive metastatic PDAC.

Identification of replication fork-associated proteins in Drosophila embryos and cultured cells using iPOND coupled to quantitative mass spectrometry

The paper identifies replication fork-associated proteins in Drosophila embryos and cultured cells using iPOND and mass spectrometry, finding BRWD3 promotes fork progression and genome stability.

Pseudomonas aeruginosa utilises host-derived polyamines to facilitate antimicrobial tolerance

This study shows that Pseudomonas aeruginosa uses host-derived polyamines, like spermidine, to enhance antimicrobial tolerance during infection, despite reduced susceptibility in vitro.

Liver Endothelium Promotes HER3-mediated Cell Survival in KRAS Wild-type and Mutant Colorectal Cancer Cells

The paper shows liver endothelial cells promote HER3-mediated survival in KRAS wild-type and mutant colorectal cancer cells through secreted factors, suggesting HER3 as a therapeutic target regardless of KRAS mutation status.

Machine learning aided top-down protein identification on a microfluidic platform

This paper demonstrates a microfluidic platform that generates multidimensional protein fingerprints, enabling high-accuracy classification using machine learning, even when single-dimensional classification fails.

On the move: Redox-dependent protein relocation

This study investigates how redox post-translational modifications regulate protein compartmentation and relocation in eukaryotic cells.

Watered-down biodiversity? A comparison of metabarcoding results from DNA extracted from matched water and bulk tissue biomonitoring samples

The paper compares DNA metabarcoding results from water and bulk benthic samples, finding that water samples poorly represent taxa compared to bulk samples.

CRISPR/Cas9 gene editing for the creation of an MGAT1 deficient CHO cell line to control HIV-1 vaccine glycosylation

This paper develops a CRISPR/Cas9-edited CHO cell line deficient in MGAT1 to produce HIV-1 gp120 with early glycosylation intermediates, enhancing binding to glycan-dependent broadly neutralizing antibodies.