C. Winter

Somatic gene delivery for flexible in vivo modeling of high-risk sarcoma

This paper develops a mouse model for high-risk sarcoma by delivering genetic lesions via electroporation, generating multiple sarcoma types and validating their molecular and therapeutic relevance.

The ER folding sensor UGGT1 acts on TAPBPR-chaperoned peptide-free MHC I

This study shows TAPBPR promotes UGGT1-mediated reglucosylation of peptide-free MHC I during quality control.

B/T cell crosstalk and aberrant inflammatory IgG exacerbate autoimmune intestinal inflammation

This study identifies B cell-driven inflammatory mechanisms, including aberrant IgG production and CD86-mediated T cell activation, as contributors to exacerbated intestinal inflammation in IBD.

Design of a systemic small molecule clinical STING agonist using physics-based simulations and artificial intelligence

This paper designs a small molecule STING agonist, SNX281, using computational methods and AI, showing systemic activity and antitumor effects in mice.

The Mutational Landscape of the SCAN-B Real-World Primary Breast Cancer Transcriptome

The paper develops a pipeline to detect mutations from RNA-seq data in breast cancer and shows it can identify mutations in key genes and pathways in 86.8% of tumors.