L. Schmitt

Molecular Insights into the bactericidal Toxin Tle1 of Pseudomonas aeruginosa: Interaction with VgrG, its adaptor, and immunity protein

This study characterizes Tle1, a bactericidal toxin from Pseudomonas aeruginosa, and identifies its interactions with VgrG4a, Tla1, and Tli1a, revealing the molecular mechanisms of its delivery and inhibition.

Somatic gene delivery for flexible in vivo modeling of high-risk sarcoma

This paper develops a mouse model for high-risk sarcoma by delivering genetic lesions via electroporation, generating multiple sarcoma types and validating their molecular and therapeutic relevance.

Above- and below-ground links mediated by arboreal ants and host tree modify soil aggregation scaling, infiltration, and chemistry

This study examines how arboreal ant nesting affects soil properties like aggregation, infiltration, and chemistry through indirect interactions with host trees and ground ants.

Monocyte production of C1q potentiates CD8+ T cell effector function following respiratory viral infection

This study shows that monocyte-produced C1q enhances CD8+ T cell function during respiratory viral infections, as demonstrated in mice and human samples.

Probing macromolecular crowding at the lipid membrane interface with genetically-encoded sensors

The paper develops a genetically-encoded fluorescence sensor to quantify macromolecular crowding at lipid membrane interfaces, finding that crowding effects depend on factors beyond molecular weight.

Novel orthotopic model of neuroblastoma in RNU homozygous rats

This study develops a novel rat neuroblastoma model to evaluate surgical treatments, showing tumor growth and feasibility of resection.

Heterologously secreted MbxA from Moraxella bovis induces a membrane blebbing response of the human host cell

The paper shows that MbxA from Moraxella bovis, secreted via an E. coli system, induces membrane blebbing and cell death in human cells.

The periplasmic chaperone Skp prevents misfolding of the secretory lipase A from Pseudomonas aeruginosa

This study shows that Skp prevents misfolding of lipase A in Pseudomonas aeruginosa and facilitates its activation by LipH, with two binding modes identified.

A MademoiseLLE domain binding platform links the key RNA transporter to endosomes

The paper identifies MLLE domains in Rrm4 as essential for endosomal attachment, revealing a hierarchical binding platform for mRNA transport.

Novel intracellular phospholipase B from Pseudomonas aeruginosa with activity towards endogenous phospholipids affects biofilm assembly

This paper identifies a novel phospholipase B from Pseudomonas aeruginosa that affects biofilm assembly by degrading phospholipids and regulating oligomerization.

A new twist in ABC transporter mediated multidrug resistance - Pdr5 is a drug/proton co-transporter

This study shows Pdr5, an ABC transporter, functions as a proton/drug co-transporter, generating a proton motive force during drug efflux, suggesting a more complex mechanism of multidrug resistance.

Cumulative growth and stress responses to the 2018-2019 drought in a European floodplain forest

The paper examines tree growth and physiological stress responses to consecutive droughts in a Central European floodplain forest, finding that cumulative stress from two hot drought years significantly impacted tree growth and carbon isotope composition.

Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5

This study reveals the structural and functional mechanism of the yeast Pdr5 transporter, showing how it uses ATP to drive drug efflux through a conformational cycle and an amphipathic channel.

Mechanism of the secretion of the lanthipeptide nisin

The paper investigates the secretion mechanism of nisin, showing that NisC modulates secretion rates while NisB's presence affects it, and that NisT's activity is influenced by maturation enzymes.

From Metapopulation to Metacommunity and the Complications of Community Structure

The paper examines metacommunity dynamics by showing that migration can lead to predator extinction in tropical leaf litter communities, corroborating findings from temperate communities.