T. Zhu

RGS10 deficiency facilitates distant metastasis by inducing epithelial-mesenchymal transition in breast cancer

This study shows RGS10 deficiency promotes breast cancer metastasis via EMT by mechanisms involving lipocalin-2 and miR-539-5p.

Novel transcriptional activator TAC3 regulates age-dependent floral transition in Chinese fir

This study identifies TAC3 and its homologues as transcriptional co-activators that regulate age-dependent floral transition by modulating miR156 expression in Arabidopsis and Chinese fir.

Endoplasmic reticulum stress delays choroid development in the HCAR1 knock-out mouse

This study shows that HCAR1 deficiency in RPE cells causes ER stress and impaired choroidal development, which is reversible with ISRIB treatment.

Floral scent emission of Epiphyllum oxypetalum: identification of a novel cytosol-localized geraniol biosynthesis pathway

This study identifies a novel cytosol-localized geraniol biosynthesis pathway in Epiphyllum oxypetalum using volatilomic, transcriptomic, and biochemical approaches.

An improved epigenetic counter to track mitotic age in normal and precancerous tissues

This paper develops and validates stemTOC, a DNA methylation-based counter for mitotic age, showing its utility in normal and precancerous tissues for cancer risk prediction.

SWI/SNF chromatin remodeling determines brassinosteroid-induced transcriptional activation

This study shows that SWI/SNF chromatin remodeling is required for BZR1-mediated transcriptional activation in Arabidopsis thaliana.

A novel bacterial signal transduction system specifically senses and responds to peptidoglycan damage

This study identifies a bacterial two-component system that detects and responds to peptidoglycan damage, revealing its role in antibiotic resistance and tolerance.

Proteomic-based stratification of intermediate-risk prostate cancer patients

The paper identifies an 18-protein signature from proteomic data to stratify intermediate-risk prostate cancer patients into low- and high-risk groups for biochemical recurrence.

Organization, genomic targeting and assembly of three distinct SWI/SNF chromatin remodeling complexes in Arabidopsis

Calcitic prisms of the giant seashell Pinna nobilis form light guide arrays

This study shows that the prismatic layer of Pinna nobilis shells functions as light guides, enhancing optical resolution and contrast for tracking movement.

The effector recognition by synthetic sensor NLR receptors requires the concerted action of multiple interfaces within and outside the integrated domain

This study shows that synthetic sensor NLR receptors require multiple interfaces within and outside their integrated domain to recognize noncorresponding effectors and activate resistance.

Potent Bacterial Vaccines Require FcγRIIB-mediated Pathogen Capture by Liver Sinusoidal Endothelium

This paper identifies FcγRIIB-mediated capture of antibody-coated bacteria by liver sinusoidal endothelial cells as a mechanism for superior vaccine efficacy.

Life cycle exposure to cyhalofop-butyl induced reproductive toxicity toward zebrafish

This study shows that long-term exposure to cyhalofop-butyl (CyB) at environmental concentrations harms zebrafish reproduction and causes developmental abnormalities in offspring.

Radiation-Induced Autophagy Regulates the Fibroblast Mitochondrial Stress Response and Crosstalk with Triple-Negative Breast Cancer Cells

This study shows that radiation-induced autophagy in fibroblasts alters their mitochondrial stress response, promoting an aggressive phenotype in triple-negative breast cancer cells.

Mammary Tissue-Derived Extracellular Matrix Hydrogels Reveal the Role of Irradiation in Driving a Pro-Tumor and Immunosuppressive Microenvironment

This study shows that irradiated mammary tissue ECM hydrogels promote TNBC cell proliferation, invasion, and immunosuppression by altering ECM composition and macrophage polarization.

CvkR, a novel MerR-type transcriptional regulator, is a repressor of class 2 type V-K CRISPR-associated transposase systems

The paper identifies Alr3614 as a repressor of type V-K CRISPR-associated transposase systems in Anabaena sp. PCC 7120 through genetic and structural analyses.

IDOL deficiency inhibits cholesterol-rich diet-induced atherosclerosis in rabbits

This study shows that IDOL deficiency reduces atherosclerosis in rabbits fed a high-cholesterol diet by improving lipid metabolism and bile acid excretion.

Actin turnover protects the cytokinetic contractile ring from structural instability

The paper uses simulations to show cofilin-mediated actin severing prevents actin bridging in fission yeast cytokinetic contractile rings.

Single-cell RNA-seq analysis reveals lung epithelial cell-specific contributions of Tet1 to allergic inflammation

This study uses single-cell RNA-seq to show that Tet1 deletion in lung epithelial cells promotes allergen-induced inflammation by altering transcriptomic networks and cell type composition.

Comprehensive RNA-Seq Reveals Molecular Changes in Kidney Malignancy Among People Living with HIV

This study uses RNA-seq to identify molecular changes in kidney cancer among people living with HIV, finding altered expression of specific genes and pathways associated with cancer progression.

The adenosine analogue prodrug ATV006 is orally bioavailable and has potent preclinical efficacy against SARS-CoV-2 and its variants

Metformin modulates microbiota-derived inosine and ameliorates methamphetamine-induced anxiety and depression-like withdrawal symptoms in mice

This paper shows metformin reduces anxiety and depression-like symptoms in mice during methamphetamine withdrawal by modulating gut microbiota-derived inosine.

BashTheBug: a crowd of volunteers reproducibly and accurately measure the minimum inhibitory concentrations of 13 antitubercular drugs from photographs of 96-well broth microdilution plates.

BashTheBug uses crowdsourced volunteers to accurately measure MICs of 13 antitubercular drugs from microdilution plates, showing median/mode of classifications is sufficient.

Small RNA profiling in Mycobacterium insights into stress adapt ability

The paper identifies stress-responsive small RNAs in Mycobacteria, finding some are linked to lipid metabolism and virulence.

Isolation and characterization of novel phages targeting pathogenic Klebsiella pneumoniae

This study isolates and characterizes three phages targeting MDR Klebsiella pneumoniae isolates, showing their lytic potential but also the emergence of phage-resistant mutants.

Auxin-responsive (phospho)proteome analysis reveals regulation of cell cycle and ethylene signaling during rice crown root development

High-speed large-scale 4D activities mapping of moving C. elegans by deep-learning-enabled light-field microscopy on a chip

This paper develops a chip-based system combining microfluidics and light-field microscopy with deep learning to high-speed 4D image and analyze moving C. elegans.

Computational optical sectioning by phase-space imaging with an incoherent multiscale scattering model

This paper introduces a computational method for optical sectioning using phase-space imaging with an incoherent multiscale scattering model, achieving improved signal-to-background ratio in biological samples.

Global reinforcement of DNA methylation through enhancement of RNA-directed DNA methylation ensures sexual reproduction in rice

This study shows that enhanced RNA-directed DNA methylation (RdDM) in reproductive organs increases DNA methylation, ensuring sexual reproduction in rice by regulating gene expression.

Specificities of and functional coordination between the two Cas6 maturation endonucleases in Anabaena sp. PCC 7120 assign orphan CRISPR arrays to three groups

This study identifies three groups of direct repeats in Anabaena sp. PCC 7120 by analyzing the specificities of two Cas6 endonucleases, showing cross-recognition and functional coordination in CRISPR-Cas systems.