Author

C.-C. Chao

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

C. Faust Akl· 2 shared F. Giovannoni· 2 shared F. J. Quintana· 2 shared G. Piester· 2 shared H.-G. Lee· 2 shared J. E. Kenison· 2 shared J. M. Rone· 2 shared L. M. Sanmarco· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

C. Faust Akl

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Disease-associated astrocyte epigenetic memory promotes CNS pathology

H.-G. Lee, J. M. Rone, Z. Li, C. Faust Akl, S. W. Shin, J.-H. Lee, L. E. Flausino, F. Pernin, C.-C. Chao, K. L. Kleemann, L. Srun, T. Illouz, F. Giovannoni, M. Charabati, L. M. Sanmarco, , F. J. Quintana

This study identifies an epigenetically controlled memory astrocyte subset that exacerbates CNS pathology in EAE and MS by promoting pro-inflammatory responses.

bioRxiv · Jan 4, 2024Immunology

Engineered probiotics limit CNS autoimmunity by stabilizing HIF-1α in dendritic cells

L. M. Sanmarco, J. M. Rone, C. M. Polonio, F. Giovannoni, G. Fernandez Lahore, K. Ferrara, C. Gutierrez-Vazquez, N. Li, A. Sokolovska, A. Plasencia, C. Faust Akl, P. Nanda, E. S. Heck, Z. Li, H.-G. Lee, , F. J. Quintana

The paper identifies an immunometabolic pathway in dendritic cells that limits autoimmunity and develops a synthetic probiotic to activate this pathway.

bioRxiv · Mar 17, 2023 · PreprintImmunology

A Noninvasive Skin Biopsy of Free Nerve Endings via Realtime Third-Harmonic Microscopy

P. J. Wu, H.-C. Tseng, C.-C. Chao, Y.-H. Liao, C.-T. Yen, W.-Y. Lin, S.-T. Hsieh, W.-Z. Sun, C.-K. Sun

This paper introduces a non-invasive third-harmonic microscopy technique to image free nerve endings and quantitatively assess small fiber neuropathy.

bioRxiv · Dec 14, 2022 · PreprintBioengineering

Single-cell transcriptome analysis of the immunosuppressive effect of differential expression of tumor PD-L1 on responding TCR-T cells

R. Ding, S. Liu, S. Wang, H. Chen, F. Wang, Q. Xu, L. Zhu, X. Dong, Y. Gu, C.-C. Chao, Q. Gao

The paper assesses how tumor PD-L1 levels impact TCR-T cell function and anti-PD-(L)1 efficacy using single-cell RNA sequencing and cellular assays.

bioRxiv · Jul 23, 2020Immunology