Author

C.-K. Chan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:large language model· 1 Research Focus:perturbation response prediction· 1 Research Focus:sequence-to-function modeling· 1 Approach:statistical model· 1

Frequent Co-Authors

H. Guo· 1 shared H. Liu· 1 shared H. Xue· 1 shared J. Guo· 1 shared J. T.-F. Wong· 1 shared J. Wu· 1 shared K. Wu· 1 shared L. Wu· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

H. Guo

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2 papers

Recent·Most cited

Target-aware Molecule Generation for Drug Design Using a Chemical Language Model

Y. Xia, K. Wu, P. Deng, R. Liu, Y. Zhang, H. Guo, Y. Cui, Q. Pei, L. Wu, S. Xie, S. Chen, X. Lu, S. Hu, J. Wu, C.-K. Chan, , T.-Y. Liu

This paper introduces TamGen, a chemical language model for target-aware molecule generation, and shows it produces high-quality compounds with inhibitory activity against Tuberculosis ClpP protease.

bioRxiv · Jan 8, 2024 · PreprintBiochemistry

An ectosymbiosis-based mechanism of eukaryogenesis

J. T.-F. Wong, X. Long, H. Xue, C.-K. Chan

This paper proposes an ectosymbiosis-based mechanism for eukaryogenesis, identifying specific prokaryotic contributors and showing a decrease in prokaryote-derived gene ratios from Microsporidia to mitochondriate eukaryotes.

bioRxiv · Mar 25, 2020Evolutionary Biology