X. Long

Hepatocyte-specific disruption of soluble epoxide hydrolase attenuates abdominal aortic aneurysm formation: novel role of the liver in aneurysm pathogenesis

This study shows that disrupting soluble epoxide hydrolase (sEH) in the liver prevents abdominal aortic aneurysm (AAA) formation by reducing inflammatory factors like C3 and SAA.

Structural Organization of the Retriever-CCC Endosomal Recycling Complex

This study determines the high-resolution structure of the Retriever-CCC endosomal recycling complex using cryo-EM and reveals how cancer mutations disrupt its function.

A life-history perspective on the evolutionary interplay of sex ratios and parental sex roles

This study uses evolutionary simulations to show that parental sex roles and sex ratios co-evolve, with parental care often biased toward the sex with lower mortality or faster maturation.

Single-molecule Mechanical Analysis of Strand Invasion in Human Telomere DNA

This study uses magnetic tweezers to form telomeric D-loops and shows that displaced DNA folds into G-quadruplexes, providing insight into telomere structure and potential therapeutic targets.

How do ecological and social environments reflect parental roles in birds? A comparative analysis

The paper examines how ecological and social environments influence parental roles in birds, finding that social environment, not ecological factors, affects sex differences in care provisioning.

Sequential ER stress and inflammatory responses are induced by SARS-CoV-2 ORF3 through ERphagy

This study identifies SARS-CoV-2 ORF3 as an inducer of ERphagy, leading to ER stress and inflammatory responses, which may be targeted for COVID-19 treatment.

Individual variation in parental care drives divergence of sex roles

The paper uses simulations to show that individual variation in parental care drives the evolution of sex roles, leading to either female- or male-biased care depending on pre-mating investment.

Single-cell RNA-seq of the stromal vascular fraction of adipose tissue reveals lineage-specific changes in cancer-related lymphedema

This study uses single-cell RNA-seq to analyze stromal vascular fraction cells in cancer-related lymphedema, identifying lineage-specific changes and potential therapeutic targets.

Single-cell RNA-seq reveals lineage-specific regulatory changes of fibroblasts and vascular endothelial cells in keloid

This study uses single-cell RNA-seq to analyze keloid tissue and identifies lineage-specific regulatory changes in fibroblasts and vascular endothelial cells, highlighting key pathways and potential therapeutic targets.

An ectosymbiosis-based mechanism of eukaryogenesis

This paper proposes an ectosymbiosis-based mechanism for eukaryogenesis, identifying specific prokaryotic contributors and showing a decrease in prokaryote-derived gene ratios from Microsporidia to mitochondriate eukaryotes.

Descent of Bacteria and Eukarya from an archaeal root of life

The paper investigates the evolutionary origins of Bacteria, Eukarya, and Archaea by analyzing gene homologies and proposes an archaeal root of life.