Author

D. D. Bigner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

D. M. Ashley· 4 shared C. J. Pirozzi· 2 shared K. Roso· 2 shared M. C. Brown· 2 shared M. Gromeier· 2 shared R. Yang· 2 shared W. Wang· 2 shared Y. He· 2 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersCancer Biology

D. M. Ashley

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Repurposing clemastine to target glioblastoma cell stemness

M. A. Sun, R. Yang, H. Liu, W. Wang, X. Song, B. Hu, N. Reynolds, K. Roso, L. H. Chen, P. K. Greer, S. T. Keir, R. E. McLendon, S.-Y. Cheng, D. D. Bigner, D. M. Ashley, , Y. He

This study shows clemastine, an antihistamine, reduces glioblastoma stemness by targeting EBP, a cholesterol pathway enzyme, and promotes differentiation of oligodendrocyte progenitor cells.

bioRxiv · Nov 5, 2022 · PreprintCancer Biology

Polio Virotherapy of Malignant Glioma Engages the Tumor Myeloid Infiltrate and Induces Diffuse Microglia Activation

Y. Yang, M. C. Brown, G. Zhang, K. Stevenson, M. Mohme, R. Kornahrens, D. D. Bigner, D. M. Ashley, G. Y. Lopez, M. Gromeier

This study investigates how PVSRIPO virotherapy activates microglia and myeloid cells in gliomas, leading to antitumor inflammation and improved outcomes when combined with PD1/PD-L1 blockade.

bioRxiv · Apr 19, 2022 · PreprintCancer Biology

Intratumor Childhood Vaccine-Specific CD4+ T cell Recall Coordinates Antitumor CD8+ T cells and Eosinophils

M. C. Brown, Z. P. McKay, Y. Yang, G. M. Beasley, D. M. Ashley, D. D. Bigner, S. K. Nair, M. Gromeier

This paper shows that childhood vaccines can enhance antitumor immunity by coordinating CD4+ T cells, CD8+ T cells, and eosinophils in mouse models and correlates these effects with human transcriptome data.

bioRxiv · Mar 14, 2022Immunology

Distribution and vulnerability of transcriptional outputs across the genome in Myc-amplified medulloblastoma cells

R. Yang, W. Wang, M. Dong, K. Roso, P. Greer, X. Bao, C. J. Pirozzi, D. D. Bigner, H. Yan, D. M. Ashley, F. Zou, V. Zhabotynsky, Y. He

This study examines the distribution of transcriptional outputs in Myc-amplified medulloblastoma cells and identifies IMPDHs as a therapeutic target.

bioRxiv · Jun 7, 2021 · PreprintCancer Biology