D. Eliezer

Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains

This paper investigates how C-terminal domains of GPCRs interact with membranes to regulate receptor function, showing that these interactions influence transducer coupling and are modulated by phosphorylation and membrane composition.

Alpha Synuclein Modulates Mitochondrial Ca2+ Uptake from ER During Cell Stimulation and Under Stress Conditions

This study shows alpha synuclein modulates mitochondrial Ca2+ uptake from ER during stimulation and stress, with distinct roles for its N-terminal and C-terminal regions.

Structure and DNA bridging activity of the essential Rec114-Mei4 trimer interface

This paper reports the structural model of the Rec114-Mei4 trimer interface and its DNA bridging activity, showing its role in meiotic DSB formation.

An environmentally ultrasensitive fluorine probe to resolve protein conformational ensembles by 19F NMR and cryo-EM

This paper introduces a fluorine probe that enhances 19F NMR sensitivity for studying protein conformational changes, validated by cryo-EM structural analysis.

Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau

This study shows that phosphorylation of tyrosine 310 in Tau reduces its aggregation and microtubule/lipid-binding properties by decreasing β-sheet propensity in the PHF6 domain.

Monitoring Dynamics of Large Membrane Proteins by 19F Paramagnetic Longitudinal Relaxation: Domain Movement in a Glutamate Transporter Homolog

The paper uses 19F-NMR and Cryo-EM to study conformational dynamics of a glutamate transporter homolog, identifying three states and measuring conformational exchange rates.

Water for sterol: an unusual mechanism of sterol egress from a StARkin domain

The paper reveals a water-controlled mechanism by which sterol exits the StARkin domain through a fracture, facilitated by hydration and polar residues.

Regulation of Exocytosis and Mitochondrial Relocalization by Alpha-Synuclein in a Mammalian Cell Model

This study shows that alpha-synuclein expression affects exocytosis in mast cells, with structural mutants impacting membrane interactions and mitochondrial association under stress.