Author

G. Lv

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biophysics· 2 Animal Behavior & Cognition· 1 Biochemistry· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:cancer & tumor microenvironment· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

D. Yang· 5 shared H. Li· 5 shared T. Zhang· 5 shared Q. Shi· 4 shared C. Yang· 3 shared H. Liu· 3 shared J. Kalashova· 3 shared N. CHOUDHRY· 3 shared

Activity by Year

2019-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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5 shared papersCancer Biology

D. Yang

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration.

G. Lv, N. M. Sayles, Y. Huang, C. D. Mancinelli, K. McAvoy, N. A. Shneider, G. Manfredi, H. Kawamata, D. Eliezer

The paper identifies amyloid fibril structures of CHCHD10 and links them to neurodegeneration, showing sequence differences between CHCHD10 and CHCHD2 allow co-aggregation.

bioRxiv · Jul 18, 2024Biophysics

Efficient cloning of genes for wheat yield component traits from QTLs via sequencing of the RIL population

M. Zhang, X. Han, H. Wang, J. Sun, B. Guo, M. Gao, H. Xu, G. Zhang, H. Li, X. Cao, N. Li, Y. Xu, Q. Wu, C. Wang, G. Zhang, , S. Li

This study develops a method to clone genes for wheat yield traits by sequencing RIL populations, identifying and validating 11 candidate genes from 77 QTLs.

bioRxiv · Feb 22, 2024 · PreprintPlant Biology

Pharmacokinetics, Tissue Distribution, and Formulation Study of a Small-molecule Inhibitor of MKLP2, LG157

N. CHOUDHRY, J. Li, T. Zhang, J. Chenyu, X. Zhou, Q. Shi, G. Lv, D. Yang

This study evaluates the drug developability of LG157, a MKLP2 inhibitor, by assessing its pharmacokinetics, tissue distribution, and formulation using SEDDS.

bioRxiv · Dec 25, 2023 · PreprintCancer Biology

MYC amplifies mitotic perturbations elicited by LXY18 to enable synthetic lethality

D. Yang, J. Kalashova, C. Yang, Y. Long, H. Li, S. Zhang, T. Zhang, D. Yu, X. Liu, G. Lv, N. Choudhry, H. Liu, Q. Shi

This study shows that LXY18 selectively kills MYC-overexpressing cancer cells by inducing mitotic arrest, offering a new approach to target MYC-driven tumors.

bioRxiv · Nov 7, 2023 · PreprintCancer Biology

Characterization of mitotic phenotypes associated with a MYC synthetic lethal compound

Q. Shi, X. Liu, J. Kalashova, C. Yang, H. Li, Y. Long, T. Zhang, S. Zhang, G. Lv, J. Huang, H. Liu, J. Zhang, T. D. Allen, D. Yang

This paper characterizes mitotic phenotypes caused by a MYC synthetic lethal compound, dimethylfasudil, showing cell cycle arrest, mitotic catastrophe, and segregation anomalies.

bioRxiv · Apr 3, 2023 · PreprintCancer Biology

An orally bioavailable 4-phenoxy-quinoline compound as a potent AURKB relocation blocker for cancer treatment

D. YANG, J. Li, T. Zhang, Q. Shi, G. Lv, X. Zhou, N. CHOUDHRY, J. Kalashova, C. Yang, H. Li, Y. Long, B. Sakthivel, N. Nimishetti, H. Liu, T. D. Allen, J. Zhang

This paper identifies LXY18, a 4-phenoxy-quinoline compound that blocks AURKB relocalization, showing potent antimitotic activity and oral bioavailability.

bioRxiv · Jan 29, 2023 · PreprintCancer Biology

A pilot study of stable isotope fractionation in Bombyx mori rearing

H. Li, Y. He, J. Lu, L. Jia, Y. Liu, D. Yang, S. Shao, G. Lv, H. Yang, H. Zheng, X. Cui, Y. Zhou, Z. Peng

This study measures stable isotope fractionation in Bombyx mori strains across life stages to trace isotope movement and understand fractionation patterns.

bioRxiv · Jan 8, 2023 · PreprintBiochemistry

Effects of short-term salinity exposure on haemolymph osmolality, gill morphology and Na+/K+ - ATPase activity in Solenaia oleivora

H. Wen, J. Yao, T. Zhang, D. Xu, G. Lv, X. Ma

This study examines the physiological responses of Solenaia oleivora to short-term salinity exposure, showing changes in hemolymph osmolality, protein and amino acid concentrations, ion levels, and gill morphology.

bioRxiv · Sep 14, 2021 · PreprintAnimal Behavior & Cognition

Monitoring Dynamics of Large Membrane Proteins by 19F Paramagnetic Longitudinal Relaxation: Domain Movement in a Glutamate Transporter Homolog

Y. Huang, X. Wang, G. Lv, A. M. Razavi, G. H. M. Huysman, H. Weinstein, C. Bracken, D. Eliezer, O. Boudker

The paper uses 19F-NMR and Cryo-EM to study conformational dynamics of a glutamate transporter homolog, identifying three states and measuring conformational exchange rates.

bioRxiv · Nov 5, 2019 · PreprintBiophysics