D. K. Scott

Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity.

This paper identifies molecular glues that stabilize the ChREBP/14-3-3 complex, protecting beta cells from glucolipotoxicity by preventing ChREBP-mediated dedifferentiation.

Human Pancreatic α-Cell Heterogeneity and Trajectory Inference Analysis Using Integrated Single Cell- and Single Nucleus-RNA Sequencing Platforms

This study identifies human α-cell and β-cell subtypes and trajectories using integrated scRNA-seq and snRNA-seq, revealing gene signatures for interconversion and highlighting in vivo transitions in T2D.

Single Cell RNA-Seq Analysis of Regenerative Drug-Treated Human Pancreatic Islets Identifies A Cycling Alpha Cell Population As Key Beta Cell Progenitors

This study uses single-cell RNA sequencing to identify cycling alpha cells as key beta cell progenitors in response to DYRK1A inhibitor treatment in human pancreatic islets.

Single Nucleus RNA Sequencing of Human Pancreatic Islets In Vitro and In Vivo Identifies New Gene Sets and Three β-Cell Subpopulations with Different Transcriptional Profile

This study compares scRNA-seq and snRNA-seq of human pancreatic islets, identifying new gene markers and three β-cell subpopulations with distinct transcriptional profiles.

Nrf2 Regulates β-cell Mass by Suppressing Cell Death and Promoting Proliferation

This study shows that Nrf2 regulates β-cell mass by reducing cell death and enhancing proliferation, suggesting it as a therapeutic target for diabetes.

HB-EGF Signaling is Required for Glucose-Induced Pancreatic β-Cell Proliferation in Rats

This study shows HB-EGF signaling is essential for glucose-induced β-cell proliferation in rats, mediated through EGFR and ChREBP pathways.

Aging Of Antiviral CD8+ Memory T Cells Fosters Increased Survival, Metabolic Adaptations And Lymphoid Tissue Homing

This study shows that aging of antiviral CD8+ memory T cells leads to increased survival, metabolic adaptations, and lymphoid tissue homing, enhancing their recall response capabilities.