C. M. Rice

This study shows that SARS-CoV-2 infection primes alveolar macrophages for enhanced antiviral responses against influenza A virus through epigenetic changes in IFN-I pathways.

This paper introduces a freeze-drying and gaseous nitrogen-based method to improve SEM imaging while preserving fluorescent signals, enabling better visualization of cellular structures and TEV-host interactions.

The paper identifies SARS-CoV-2 peptides presented by HLA-II complexes, showing their association with CD4+ T cell epitopes and distinct targeting of viral proteins compared to HLA-I.

The paper infects diverse mouse strains with a hepacivirus and shows host genetic variation influences viral clearance, chronicity, and liver fibrosis outcomes.

This study shows that anti-DENV IgG antibodies drive dengue pathogenesis via FcγRIIIa on splenic macrophages, leading to inflammation and mortality.

This paper describes a second-generation recombinant MVA vaccine that enhances antitumor immunity by reprogramming myeloid and T cells through innate-adaptive IFN cross-talk.

The paper develops human monoclonal antibodies targeting the ACE2 receptor to block infection by SARS-CoV-2 and related sarbecoviruses, showing broad efficacy against variants and no adverse effects on ACE2 function.

The paper identifies conserved neutralizing epitopes on the N-terminal domain of SARS-CoV-2 spike proteins using NTD-specific probes and characterizes antibodies that neutralize multiple variants.

This study shows that convalescent individuals with or without vaccination maintain neutralizing activity and memory B cells against SARS-CoV-2 for up to one year, with vaccination enhancing breadth and potency against variants.

This study shows that the PNPLA3 148M variant in human hepatocytes worsens non-alcoholic steatohepatitis in chimeric mice on a hypercaloric diet.

The paper identifies host factors required for SARS-CoV-2 and three seasonal coronaviruses using CRISPR screens, revealing shared and virus-specific dependencies.

The paper identifies HLA-I peptides from SARS-CoV-2 in infected cells, revealing epitopes from both canonical and out-of-frame ORFs, which could inform vaccine development.

The paper identifies host factors critical for SARS-CoV-2 and related coronaviruses using CRISPR screens, revealing both shared and unique factors across different viruses and temperatures.

This study shows that secretory IgA, particularly dimers, are more potent than IgG in neutralizing SARS-CoV-2 in vitro, suggesting their importance for mucosal protection and vaccine design.

This study identifies LY6E as an interferon-induced gene that restricts coronavirus entry and pathogenesis by inhibiting spike protein-mediated fusion and protecting immune cells.

The paper describes assays using pseudotyped and chimeric viruses to measure SARS-CoV-2 neutralizing antibody activity, showing correlation with authentic assays.

This study identifies a histone-like motif in the yellow fever virus capsid protein that mimics histone H4 and interferes with BRD4-mediated gene regulation, impacting viral replication.

The paper identifies broadly neutralizing antibodies against HBV in elite neutralizers and shows that combinations of bNAbs targeting different epitopes are more effective than single bNAbs.

This study shows that two Fc-modified monoclonal antibodies limit fetal neurologic damage and vertical transmission of ZIKV in pregnant macaques.

The paper shows that lung type II alveolar epithelial cells induce IFN-beta and recruit CCR2+ monocytes to combat vaccinia virus infection.

This paper describes an RNA-based system to study HBV replication and predict drug resistance mutations.