U. Dittmer

Targeted mutations in IFNα2 improve its antiviral activity against various viruses

The paper identifies critical antiviral residues in IFN subtypes and designs improved IFN molecules with enhanced antiviral activity against HIV and HBV.

Cellular hnRNPA0 limits HIV-1 production by interference with LTR-activity and programmed ribosomal frame-shifting

This study shows hnRNPA0 limits HIV-1 replication by inhibiting LTR activity and ribosomal frameshifting, with lower expression in HIV-infected individuals.

Interferon-α subtype treatment induces the repression of SRSF1 in HIV-1 target cells and affects HIV-1 post integration steps

This study shows that IFN-α treatment represses SRSF1 in HIV-1 target cells, affecting post-integration viral replication steps by altering splicing and transcription.

Differential interferon-α subtype immune signatures suppress SARS-CoV-2 infection

The paper identifies differential antiviral effects of IFN-alpha subtypes against SARS-CoV-2 and highlights IFN5's superior activity, suggesting therapeutic potential.

Comparable environmental stability and disinfection profiles of the currently circulating SARS-CoV-2 variants of concern B.1.1.7 and B.1.351

This study compares the environmental stability and disinfection profiles of SARS-CoV-2 variants B.1.1.7 and B.1.351 to the wildtype, finding comparable susceptibility to disinfection and surface stability.

Occurrence of COVID-19 symptoms during SARS-CoV-2 infection defines waning of humoral immunity

The study compares antibody responses in asymptomatic and symptomatic SARS-CoV-2感染者, finding that symptomatic individuals maintain higher and longer-lasting IgG and neutralizing capacities.

Disinfection of SARS-CoV-2 contaminated surfaces of personal items with UVC-LED disinfection boxes

This study evaluates the effectiveness of UVC-LED disinfection boxes in inactivating SARS-CoV-2 on personal item surfaces, showing significant viral load reduction after 3 minutes of exposure.

The CCL2 Chemokine Promotes Early Seeding of the Latent HIV Reservoir

This study shows that CCL2 chemokine promotes early HIV reservoir formation by recruiting CCR2/5+ CD4 T cells to sites of inflammation during acute infection.

Universally available herbal teas based on sage and perilla elicit potent antiviral activity against SARS-CoV-2 variants of concern by HMOX-1 upregulation in human cells

Cell-to-cell spread inhibiting antibodies constitute a correlate of protection against Herpes Simplex Virus Type 1 reactivations

The paper identifies cell-to-cell spread inhibiting antibodies as a correlate of protection against HSV-1 reactivations by screening plasma samples and correlating antibody levels with reactivation frequency.

Impaired cytotoxic CD8+ T cell response in elderly COVID-19 patients

This study examines CD8+ T cell cytotoxicity in mild COVID-19 patients, finding reduced cytotoxic potential in elderly individuals over 80 years old.

Holder Pasteurization Inactivates SARS-CoV-2 in Human Breast Milk

This study shows that Holder pasteurization inactivates SARS-CoV-2 in human breast milk, offering a safe method for infected mothers to breastfeed.

A novel in-cell ELISA assay allows rapid and automated quantification of SARS-CoV-2 to analyse neutralizing antibodies and antiviral compounds

Type I interferons sensitise HIV-1-reactivating T-cells for NK cell-mediated elimination despite HDACi-imposed dysregulation of innate immunity

This study shows that type I interferons can enhance NK cell killing of HIV-1-reactivating T-cells despite HDACi-induced immune dysregulation, suggesting a potential strategy to improve shock-and-kill approaches.

Prophylactic and therapeutic HBV vaccination by an HBs-expressing cytomegalovirus vector lacking an interferon antagonist

This study shows that HBV vaccines based on modified CMV vectors can clear HBV in mice through enhanced CD8+ T cell responses in both prophylactic and therapeutic settings.

HIV infection does not alter Interferon α/β receptor expression on mucosal immune cells

This study investigates whether HIV infection alters IFNAR2 expression on mucosal immune cells and finds no significant changes in IFNAR2 expression in HIV+ patients or after HIV-1 infection ex vivo.