M. Trilling

The human cytomegalovirus-encoded pUS28 antagonizes CD4+ T-cell recognition by targeting CIITA

This study identifies pUS28 as a viral protein that inhibits CIITA-driven HLA-II expression, thereby blocking CD4+ T-cell recognition of HCMV-infected cells.

Targeted mutations in IFNα2 improve its antiviral activity against various viruses

The paper identifies critical antiviral residues in IFN subtypes and designs improved IFN molecules with enhanced antiviral activity against HIV and HBV.

Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning

This study investigates how HCMV US10 protein regulates HLA-I genotype and surface expression, revealing its multimodal effects on different HLA-I allotypes.

Structure and mechanism of a novel cytomegaloviral DCAF mediating interferon antagonism

This study identifies E27 as a viral protein that targets STAT2 for degradation via CRL4 ubiquitin ligases, revealing its structural mechanism of interferon antagonism.

Acute Cytomegalovirus Infection Modulates the Intestinal Microbiota and Targets Intestinal Epithelial Cells

This study shows that acute CMV infection alters gut microbiota and targets intestinal epithelial cells, leading to colitis in immunocompetent hosts.

Multi-omics reveals principles of gene regulation and pervasive non-productive transcription in the human cytomegalovirus genome

The paper uses multi-omics data to model HCMV gene regulation, identifying over 2,600 viral transcripts and explaining protein expression kinetics through transcription start sites and RNA stability.

Differential interferon-α subtype immune signatures suppress SARS-CoV-2 infection

The paper identifies differential antiviral effects of IFN-alpha subtypes against SARS-CoV-2 and highlights IFN5's superior activity, suggesting therapeutic potential.

Occurrence of COVID-19 symptoms during SARS-CoV-2 infection defines waning of humoral immunity

The study compares antibody responses in asymptomatic and symptomatic SARS-CoV-2感染者, finding that symptomatic individuals maintain higher and longer-lasting IgG and neutralizing capacities.

Universally available herbal teas based on sage and perilla elicit potent antiviral activity against SARS-CoV-2 variants of concern by HMOX-1 upregulation in human cells

SARS-CoV-2-specific T cell memory is long-lasting in the majority of convalsecent COVID-19 individuals

This study shows that SARS-CoV-2-specific T cell memory persists for at least 9 months in most convalescent COVID-19 individuals, with some responses lasting longer.

Cell-to-cell spread inhibiting antibodies constitute a correlate of protection against Herpes Simplex Virus Type 1 reactivations

The paper identifies cell-to-cell spread inhibiting antibodies as a correlate of protection against HSV-1 reactivations by screening plasma samples and correlating antibody levels with reactivation frequency.

Impaired cytotoxic CD8+ T cell response in elderly COVID-19 patients

This study examines CD8+ T cell cytotoxicity in mild COVID-19 patients, finding reduced cytotoxic potential in elderly individuals over 80 years old.

A novel in-cell ELISA assay allows rapid and automated quantification of SARS-CoV-2 to analyse neutralizing antibodies and antiviral compounds

Prophylactic and therapeutic HBV vaccination by an HBs-expressing cytomegalovirus vector lacking an interferon antagonist

This study shows that HBV vaccines based on modified CMV vectors can clear HBV in mice through enhanced CD8+ T cell responses in both prophylactic and therapeutic settings.