R-loop homeostasis and cancer mutagenesis promoted by the DNA cytosine deaminase APOBEC3B
J. McCann, A. Cristini, E. Law, S. LEE, M. Tellier, M. Carpenter, C. Beghe, J. Kim, M. C. Jarvis, B. Stefanovska, N. A. Temiz, E. N. Bergstrom, D. Salamango, M. Brown, S. Murphy, , R. Harris
This study shows APOBEC3B regulates R-loop homeostasis and contributes to mutagenesis in cancer by binding R-loops and altering their landscape.
bioRxiv · Aug 30, 2021 · PreprintCancer Biology