W. Brown

MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention

This study shows MKP1 suppresses AMPK activity via LKB1 nuclear retention, promoting NASH by inducing hepatocyte death and inflammation.

Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer

This study quantifies the mutagenic activities of APOBEC3A and APOBEC3B in a human cell line and compares their mutation signatures to breast cancer genomes, showing both enzymes contribute to the mutation landscape.

The MS remyelinating drug bexarotene (an RXR agonist) promotes induction of human Tregs and suppresses Th17 differentiation in vitro

This study shows bexarotene, an RXR agonist, promotes Treg induction and suppresses Th17 differentiation in human CD4 T cells, independent of tRA and RAR signaling.

An immunogenic model of KRAS-mutant lung cancer for study of targeted therapy and immunotherapy combinations

This paper develops an immunogenic mouse model of KRAS-mutant lung cancer that responds to immunotherapy and reveals immune responses target endogenous retroviral antigens rather than neoantigens.

A rabbit monoclonal antibody against the antiviral and cancer genomic DNA mutating enzyme APOBEC3B

This paper describes the generation and characterization of a rabbit monoclonal antibody against APOBEC3B, showing its potential as a research tool and clinical biomarker for cancer.

Biased signaling downstream of epidermal growth factor receptor regulates proliferative versus apoptotic response to ligand

This paper shows that in metastatic breast cancer, EGFR signaling is biased toward STAT1, leading to apoptosis, and that pharmacological biasing can enhance this effect.

The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by a RNA-Mediated Dimerization Mechanism

This study identifies an RNA-mediated dimerization mechanism that regulates APOBEC3H DNA deaminase activity, localization, and antiviral function.